Autoimune

Question 0

Four ANA patterns are

Answer 0

Speckled
Homogenous
Nucleolar
Peripheral (rim)

Question 1

Speckled ANA seen in

Answer 1

Sjogren's
SLE
RA
dermato/poly
PBC
scleroderma

Question 2

ANA with nucleolar pattern

Answer 2

Scleroderma

Question 3

Hashimotos

Answer 3

Target: thyroglobulin, thyroid peroxidase

Question 4

Graves

Answer 4

Target tsh receptor

Question 5

Goodpasture syndrome

Answer 5

Target type 4 collagen

Question 6

Addison

Answer 6

Target cytochrome P450 antigens

Question 7

Peripheral (rim) pattern

Answer 7

dsDNA seen in SLE and drug induced lupus

Question 8

ANA homogenous pattern seen in

Answer 8

Target is DNA histone complexes
SLE
drug induced lupus
RA

Question 9

RA associated with which haplotype

Answer 9

HLA DR4

Question 10

Acquired C1 inhibitor deficiency

Answer 10

Age 30 or more
Clinically similar to hereditary angioedema
recurrent angioedema without pruritis or urticaria
70 percent associated NHL or MGUS or other lymphoproliferative disorder or cancer
Most have autoAb against C1 inhibitor protein but precise path not defined
Check NO family hx
Test C4 C1q and C1 inhibitor level . Then low C1 inhibitor function obtained to clinch dx
Don’t use ACEI as bradykinin is the mediator

Question 11

Autoimmune hepatitis type 2

Answer 11

Anti-liver/kidney microsomal-1 (anti-LKM-1) antibodies
Anti-liver cytosol-1 (anti-LC1) antibodies
Anti-SLA/LP

Question 12

PBC

Answer 12

AMA

Question 13

Autoimmune hepatitis type 1

Answer 13

Antinuclear antibodies (ANA)
Anti-smooth muscle antibodies (ASMA)
Anti-actin antibodies (AAA)
Anti-soluble liver/liver pancreas antigen (anti-SLA/LP)- most specific
Atypical perinuclear antineutrophil cytoplasmic antibodies (pANCA)
Antimitochondrial antibodies (AMA)