immunology

Question 1

anti-ACh receptor

Answer 1

Myesthenia Gravis

Question 2

Anti-BM

Answer 2

Goodpasture syndrome

Question 3

Anticardiolipin

Answer 3

SLE, antiphospholipid syndrome

Question 4

Lupus anticoagulant

Answer 4

SLE, antiphospolipid syndrome

Question 5

Anticentomere

Answer 5

CREST syndrome (limited scleroderma)

Question 6

Anti-desmosome (anti-desmoglein)

Answer 6

Pemphigus Vulgaris

Question 7

Anti-dsDNA

Answer 7

SLE

Question 8

Anti-Smith

Answer 8

SLE

Question 9

Anti-glutamic acid decarboxylase (GAD-65)

Answer 9

Type I DM

Question 10

Antihemidesmosome

Answer 10

Bullous Pemphigoid

Question 11

Anti-histone

Answer 11

Drug-induced lupus

Question 12

Anti-jo-1

Answer 12

polymyositis, dermatomyositis

Question 13

Anti-SRP

Answer 13

polymyositis, dermatomyositis

Question 14

antimicrosomal

Answer 14

hashimoto thyroiditis

Question 15

antithyroglobulin

Answer 15

hashimoto thyroiditis

Question 16

antimitochondrial

Answer 16

primary biliary cirrhosis

Question 17

Antinuclear antibodies

Answer 17

SLE, nonspecific

Question 18

Antiparietal cell

Answer 18

pernicious anemia

Question 19

Anti-Scl-70

Answer 19

scleroderma, diffuse

note: aka anti-DNA topoisomerase I

Question 20

anti-DNA topoisomerase I

Answer 20

scelroderma, diffuse

note: aka anti-Scl-70

Question 21

anti-smooth muscle

Answer 21

autoimmune hepatitis

Question 22

anti-SSA

Answer 22

Sjogren syndrome

note: aka anti-Ro

Question 23

Anti-Ro

Answer 23

Sjogren syndrome

note: aka anti-SSA

Question 24

anti-SSB

Answer 24

Sjogren syndrome

note: aka anti-La

Question 25

anti-La

Answer 25

Sjogren syndrome note: aka anti-SSB

Question 26

Anti-TSH receptor

Answer 26

Graves disease

Question 27

Anti-U1 RNP (ribonucleoprotein)

Answer 27

mixed CT disease

Question 28

IgA anti-endomysial

Answer 28

Celiac disease

Question 29

IgA anti-tissue transglutaminase

Answer 29

Celiac disease

Question 30

MPO-ANCA

Answer 30

microscopic polyangiitis, eosinophilic granulomatosis with polyangitis (Churg-Strauss syndrome)

Question 31

p-ANCA

Answer 31

microscopic polyangiitis, eosinophilic granulomatosis with polyangitis (Churg-Strauss syndrome)

Question 32

PR3-ANCA

Answer 32

granulomatosis with polyangiitis (Wegener)

Question 33

c-ANCA

Answer 33

granulomatosis with polyangiitis (Wegener)

Question 34

Rhuematoid factor

Answer 34

= IgM antibody that targets IgG Fc region Rheumatoid arthritis

Question 35

anti-CCP

Answer 35

Rheumatoid arthritis more specific than RF

Question 36

Aldesleukin

Answer 36

IL-2 | RCC, metastatic melanoma

Question 37

Epoetin alfa

Answer 37

EPO | anemias, esp renal failure

Question 38

Filgrastim

Answer 38

G-CSF | recovery of bone marrow

Question 39

Sargramostim

Answer 39

GM-CSF | recovery of bone marrow

Question 40

IFN-alpha

Answer 40

chronic Hep B and C Kaposi sarcoma malignant melanoma

Question 41

IFN-beta

Answer 41

MS

Question 42

IFN-gamma

Answer 42

chronic granulomatous disease

Question 43

Romiplostim

Answer 43

thrombocytopenia

Question 44

Eltrombopag

Answer 44

thrombocytopenia

Question 45

Oprelvekin

Answer 45

IL-11 | thrombocytopenia

Question 46

alemtuzumab

Answer 46

targets CD52 for CLL

Question 47

bevacizumab

Answer 47

targets VEGF for colorectal cancer RCC

Question 48

Cetuximab

Answer 48

targets EGFR for stage IV CRC H/N Ca

Question 49

Rituximab

Answer 49

targets CD 20 for B-cell NHL CLL RA ITP

Question 50

Trastuzumab

Answer 50

targets Her2/neu for BC

Question 51

Adalimumab

Answer 51

targets soluble TNF-alpha for IBD, RA, ankylosing spondylitis, psoriasis

Question 52

Infliximab

Answer 52

targets soluble TNF-alpha for IBD, RA, ankylosing spondylitis, psoriasis

Question 53

Etanercept

Answer 53

targets soluble TNF-alpha - decoy TNF-alpha receptor (not monoclonal antibody) for IBD, RA, ankylosing spondylitis, psoriasis

Question 54

Eculizumab

Answer 54

targets complement protein C5 for Paroxysmal nocturnal hemoglobinuria

Question 55

Natalizumab

Answer 55

targets alpha 4 integrin for MS, Crohn disease risk of PML in pts with JC virus

Question 56

Abciximab

Answer 56

targets platelet glycoproteins IIb/IIIa for prevention of ischemic complications in patients undergoing percutaneous coronary interventions

Question 57

Denosumab

Answer 57

targets RANKL for osteoporosis - inhibits osteoclast maturation (mimics osteoprotegerin)

Question 58

Digoxin immune Fb

Answer 58

targets Digoxin antidote for digoxin toxicity

Question 59

Omalizumab

Answer 59

targets IgE for allergic asthma prevent IgE binding to Fc epsilon RI

Question 60

Palivizumab

Answer 60

targets RSV F protein for RSV prophylaxis for high-risk infants

Question 61

Ranibizumab

Answer 61

targets VEGF for neovascular age-related macular degeneration

Question 62

parasite associated with biliary tract disease

Answer 62

clonorchis sinensis

Question 63

parasite associated with cholangiocarcinoma

Answer 63

clonorchis sinensis

Question 64

parasite associated with brain cysts and seizures

Answer 64

taenia solium (cysticercosis)

Question 65

parasite associated with hematuria

Answer 65

schistosoma haematobium

Question 66

parasite associated with bladder cancer

Answer 66

schistosoma haematobium

Question 67

parasite associated with liver (hydatid) cysts

Answer 67

echinococcus granulosus

Question 68

parasite associated with microcytic anemia

Answer 68

ancylostoma, necator

Question 69

parasite associated with myalgias

Answer 69

trichinella spiralis

Question 70

parasite associated with periorbital edema

Answer 70

trichinella spiralis

Question 71

parasite associated with perianal pruritis

Answer 71

enterobius

Question 72

parasite associated with portal hypertension

Answer 72

schistosoma mansoni, schistosoma japonicum

Question 73

parasite associated with vitamin B12 deficiency

Answer 73

diphyllobothrium latum