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Biochem; Re > Immunology > Flashcards

Immunology Flashcards

1
Q

Determines isotype of an antibody

A

Heavy chains of the Fc region 📌

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2
Q

Hinge region of antibody

A

Bet CH1 and CH2 domains

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3
Q

Visualize the antibody

A

half
Fab region:
VL, VH
CL, CH1

hinge region

Fc region:
CH2
CH3

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4
Q

Complement binding

A

CH2

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5
Q

Macrophage binding

A

CH2, CH3

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6
Q

Mimotope

A 
A macromolecule (often a peptide) which mimics the structure of an EPITOPE
Causes an antibody response similar to the one elicited by the epitope
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7
Q

Present in both innate and adaptive immunity

A

Macrophage

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8
Q

Antigen presenting cells

A

Macrophage
Dendritic cells
B cells?

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9
Q

Lymphocytes in the spleen

A

B cells: white pulp

T cells: periarteriolar lymphoid sheaths (PALS)

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10
Q

Products of basophil

A

Histamine
Heparin
Bradykinin
Serotonin

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11
Q

1st line of defense

A

Tissue macrophages

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12
Q

2nd line of defense

A

Neutrophils invasion

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13
Q

3rd line of defense

A

Monocyte —> macrophage

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14
Q

Remarks on immunoglobulins

A

10^15 possible different immunoglobulins

Serum concentrations: GAMDE

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15
Q

Function of IgD

A

Enhance mucosal homeostasis and immune surveillance

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16
Q

Remarks on T cells

A

Although B cells recognize intact antigens, T cells respond to antigens ONLY when they are bound to MHC PROTEINS on the surface of APCs in the lymphoid tissues
There are as many as 100,000 receptor sites on a single T cell

17
Q

3 major types of types of APC

A

DuMB
DENDRITIC CELLS (most potent)
MACROPHAGES
B CELLS

18
Q

Remark/s on dendritic cells

A

Most potent of the APCs
Located throughout the body
Their only known function is to present antigens to T cells

19
Q

Most numerous of the T cells

A

T-helper cells (75%)

20
Q

Pangsaludo ni macrophage kay T helper cell

A

IL-1

21
Q

IL-1-6

A

IL-1

  • from macrophages
  • stimulates T helper cells

IL-2

  • from TH1 cells
  • stimulates cytotoxic T cells
  • suppressor T cells
  • memory T cells

IL-4,5,6

  • from TH2 cells
  • stimulates B cells
  • “B cell growth factors” (Guyton)
  • IL4: IgE class switching
  • IL5: differentiation of eosinophils
  • IL-6: overproduced in castleman disease
22
Q

Endogenous chemotactic signals

A

IL-8
C5a
Leukotriene B4

23
Q

IL-12

A
  • from macrophages and B cells

- stimulates production of interferon by TH1 cells and by NK cells

24
Q

Cytokins for immunesuppressin

A

Matabang B-ga10
Lipoxin
TGF-B
IL-10

25
Q

Antibodies via passive immunity last for

A

2-3 weeks

26
Q

HSR of poison IV

A

4?

Biochem; Re (11 decks)

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