Immunology Flashcards
What T cell subset contains a receptor for CD8?
a. T helper cells
b. Both T helper and T killer cells
c. T cytotoxic cells
d. T suppressor cells
C
CD4: T helper
CD8: T cyt
Which type of hypersensitivity reaction is involved in
tuberculosis, contact dermatitis and organ transplant rejection?
a. Type i
b. Type II
c. Type III
d. Type IV
D
Which of these characteristics best describes innate immunity?
a. Conferment of non-specific defense system
b. Rapid response to antigens
c. Presence of cellular and humoral mechanisms
d. Presence of immunologic memory
A
Which of these cells are considered large granular lymphocytes
and play a role in protection against viruses?
a. NK cells
b. B cells
c. T cells
d. Plasma cells
A
Which of these play a role in the alternate pathway of
complement activation?
a. Factor B
b. C2
c. C4b2a3b
d. C1q
A
What fragment of the antibody attaches to the 1st complement
component in the classical pathway of complement activation?
a. Fc Fragment
b. Fab
c. C1q
d. C1r
A
Trimolecular complex (C1qrs) -
binds to Fc fragment
C & D - part of C1
Which type of hypersensitivity reaction is involved in
tuberculosis, contact dermatitis, and organ transplant rejection?
a. Type II
b. Type IV
c. Type I
d. Type III
B
Type I - Allergy
Type II - blood transfusions (blood
related)
Type III - immune complex reactions
Which of these characteristics best describe innate immunity?
a. Conferment of non specific defense system
b. Rapid response to antigens
c. Presence of cellular and humoral mechanisms
d. Presence of immunologic memory
A
B-D Adaptive immunity
Which of these is an effect of cytokines?
a. Release of interleukins and tumor necrosis factor from
WBCs
b. Alteration of cell shape during diapedesis
c. Transformation of antibiotics from plasma cells
d. Production of natural killer cells from the bone marrow
A
Cytokines - recruit and activate
macrophages (IL-8, IL-1, TNF)
Which of these functions is unique to IgA?
a. It is the only one that crosses the placenta
b. It is most abundant in secretions and mucous
membranes
c. Appearance in blood occurs during the anamnestic
response
d. It is predominantly seen in hypersensitivity reactions
B
Explanation:
A - IgG
C - IgM -> IgG
D - IgE
Which of these functions characterize natural killer cells?
a. They recognize and kill virus infected cells and tumor
cells
b. Their functions are MHC restricted
c. They are involved in hypersensitivity reactions
d. They are responsible for the production of antibodies
A
B T Cells
C Eosinophils
D B Cells
Which of these cells are considered large granular lymphocytes and play a role in protection against viruses?
a. T cells
b. B cells
c. Natural killer cells
d. Plasma cells
C
A recognize and kill virus infected cells and tumor cells B produce of antibodies D activated B cells that produce antibodies
What T cell subset contains a receptor for CD8?
a. T helper
b. T cytotoxic
c. T suppressor
d. Both T helper and T killer
B
T helper: CD4
Which of these plays a role in the alternate pathway of
complement activation?
a. C1q
b. C4
c. Factor B
d. C2
C
- Classical - C1q, C1r, C1s, IgG/ IgM
- Alternate - C3, Factor B, Factor D,
LPS (bacterial capsule), IgA - Lectin - MBP, MASP-1, MASP-2,
Mannose groups on microbial cell
Which antibody is found mostly in body secretion and body fluids?
a. IgG
b. IgA
c. IgM
d. IgE
B
Recall
Which of these functions best describe the complement
system?
a. It serves as a rapid initial response to acute infection
b. Production of antibodies to neutralize infection
c. Generates reactive oxygen species
d. Cell lysis through the development of the membrane
attack complex
D
A Innate immunity
B Adaptive immunity
C - Innate Immunity
Which fragment of the antibody molecule is the attachment point of the first component in the classical pathway?
a. Fab
b. Fc
c. Both fragments
d. Neither of the two
B
Recognition Unit of Classical
Pathway - C1q binds to the Fc
region of the antibody
