Immunological tolerance

Question 1

Where does B cell central tolerance occur?

Answer 1

bone marrow

Question 2

B cell central tolerance

Answer 2

receptor editing

apoptosis

Question 3

B cell peripheral tolerance

Answer 3

apoptosis
anergy
clonal ignorance

Question 4

Where does T cell central tolerance occur?

Answer 4

thymus

Question 5

T cell central tolerance

Answer 5

positive selection

negative selection

Question 6

What cells undergo positive selection?

Answer 6

thymic epithelial cells

Question 7

What cells undergo negative selection?

Answer 7

macrophages

DCs

Question 8

Positive selection cells that do not bind MHC molecules

Answer 8

apoptosis

Question 9

Positive selection Bind class II molecules

Answer 9

mature to CD4 cells

Question 10

positive selection bind class I molecules

Answer 10

mature to CD8 cells

Question 11

negative selection strongly bind self-MHC or self antigen

Answer 11

apoptosis

Question 12

negative selection some self reactive CD4 cells develop into…

Answer 12

t regs

Question 13

T cell peripheral tolerance

Answer 13

apoptosis

Clonal ignorance/anergy

Question 14

TCR affinity for antigen in T cell peripheral tolerance

Answer 14

self MHC complex too low for T cell to be removed

Question 15

t/f all self antigens are expressed in the thymus

Answer 15

false

Question 16

T/f self reactive T cells cannot infiltrate into immunologically privileged sites

Answer 16

true

Question 17

antigen in t cell peripheral tolerance

Answer 17

expressed in too low amounts

affinity for TCR too low to trigger response

Question 18

t cell peripheral tolerance and apcs

Answer 18

absence of co-stim molecules on apcs

Question 19

what induce t cell anergy in t cell peripheral tolerance?

Answer 19

tregs

tolerogenic DCs

Question 20

Loss of tolerance results in what?

Answer 20

autoimmunity

Question 21

How can infection break tolerance?

Answer 21

• disrupt tissue barrier
• infect APCs
• bind pathogen to self proteins
• molecular mimicry
• superAg

Question 22

specific immunological non-reactivity to an antigen resulting from a previous exposure to same antigen

Answer 22

immunological tolerance

Question 23

need to induce tolerance

Answer 23

transplantation

Question 24

need to break tolerance

Answer 24

cancer

Question 25

when does central tolerance occur?

Answer 25

during development

Question 26

when does peripheral tolerance occur?

Answer 26

following development

Question 27

B cell peripheral tolerance apoptosis

Answer 27

b cells strongly bind to self antigens

Question 28

b cell peripheral tolerance anergy

Answer 28

b cells bind to soluble self-antigens

Question 29

b cell peripheral tolerance clonal ignorance

Answer 29

b cells bind to low affinity non cross liking self antigens

Question 30

failure to delete self-reactive b and t cells through apoptosis

Answer 30

loss of tolerance

Question 31

peripheral tolerance in periphery may fail

Answer 31

loss of tolerance

Question 32

two groups of auto antigens in loss of tolerance

Answer 32

• tissue specific

- ubiquitous

Question 33

superantigen

Answer 33

RA

Question 34

molecular mimicry

Answer 34

rheumatic fever

Question 35

disruption of cell or tissue barrier

Answer 35

sympathetic ophthalmia