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Immune Exam 3 > autoimmunity > Flashcards

autoimmunity Flashcards

1
Q

how many americans suffer from autoimmune disorders?

A

1 in 12

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2
Q

Environmental triggers have helped to ______ disease rates

A

triple

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3
Q

how many autoimmune diseases are there?

A

100

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4
Q

why is there an increase in autoimmune diseases?

A
  • environmental factors
  • diet
  • stress
  • hormones
  • aging
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5
Q

do autoimmune diseases affect men or women more?

A

women

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6
Q

autoimmune disease where antibodies or t cells to a single organ

A

organ specific

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7
Q

graves disease organ specific or systemic?

A

organ specific

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8
Q

T1D organ specific or systemic?

A

organ specific

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9
Q

Goodpastures syndrome organ specific of systemic?

A

organ specific

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10
Q

Addison disease organ specific or systemic?

A

organ specific

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11
Q

thyroid stimulating Igs

A

Graves disease

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12
Q

insulin receptor and other islet Ags

A

T1D

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13
Q

basement membrane collagen in lungs and kidneys

A

goodpastures syndrome

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14
Q

proteins in adrenal cortex

A

addison disease

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15
Q

autoimmune disease where target antigens are among many tissues

A

systemic

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16
Q

SLE organ specific or systemic?

A

systemic

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17
Q

RA organ specific or systemic?

A

systemic

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18
Q

Sjogren syndrome (SS) organ specific or systemic?

A

systemic

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19
Q

Vasculitis organ specific or systemic?

A

systemic

20
Q

dsDNA and intracellular nucleoproteins; form large amounts of immune complexes

A

SLE

21
Q

antibodies to IgG fc and CCP, auto reactive T cells in joints

A

RA

22
Q

antibodies to ribonucleoproteins SSA and SSB

A

SS

23
Q

antibodies to neutrophil cellular ags

A

vasculitis

24
Q

Three interacting influences on development of autoimmune diseases

A
  • genes
  • immune regulation
  • environment
25
Q

t/f MHC alleles strongly contribute to genetic susceptibility to autoimmune diseases

A

true

26
Q

failure to negatively select auto reactive clones or preferentially present autoantigens

A

differential selection

27
Q

How do infections facilitate autoimmunity?

A

activation of auto reactive b and t lymphocytes

28
Q

mechanisms of tissue damage and autoimmune diseases

A
  • autoantibodies
  • auto reactive t cells
  • immune complex tissue deposition
29
Q

autoantibodies

A
  • activate complement

- activate immune effector cells

30
Q

auto reactive t cells

A
  • cytotoxic t cell destruction of tissue

- release inflammatory cytokines

31
Q

immune complex tissue deposition

A

activate complement and immune effector cells type ii autoimmunity

32
Q

type II autoimmunity

A

IgG mediated cytotoxic hypersensitivity

33
Q

type II autoimmunity example

A

hemolytic anemia

34
Q

type III autoimmunity

A

immune complex mediated hypersensitivity

35
Q

type III autoimmunity example

A

glomerulonephritis
RA
SLE

36
Q

type IV autoimmunity

A

cell mediated hypersensitivity

37
Q

type IV autoimmunity example

A

T1D
MS
RA

38
Q

Red wolf disease

A

SLE

39
Q

Chronic auto reactive IgG production

A

SLE

40
Q

Activation of auto reactive T cells and autoantibodies to CCP

A

RA

41
Q

Activation of auto reactive T cells and autoantibodies to myelin

A

MS

42
Q

Treatments for autoimmune diseases

A
  • metabolic control
  • conventional immunosuppresants
  • biologicals
43
Q

what do biologicals target?

A

TNF-a

44
Q

types of autoimmune diseases

A

organ specific

systemic

45
Q

Metabolic control examples

A
  • thyroxin
  • insulin
  • B12
46
Q

Immunosuppressant examples

A
  • steroids

- nsaids

47
Q

biologicals examples

A
  • Remade
  • Humira
  • Enbrel

Immune Exam 3 (5 decks)

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