Immunologic injury Flashcards
complementary medicine
labor intensive, makes you feel good
alternative medicine
stuff that fails basic controlled equipoise studies
evidence based medicine
stuff that works no matter who discovers it even if it won’t make money
hapten
atom or molecule that binds to a body protein, then the adduct is attacked by the immune system
i.e. nickel, poison ivy, penicillin
where do b cells undergo maturation
germinal follicles of lymph nodes
plasma cells make what and are where
make antibodies, found in tissues
hypersensitivity
disease caused by immune system attacking itself or antigens from environment
Type 1 immune injury
mast cells
Th2/igE/mast cell/eosinophil (worms)
whats the first consideration of eosinophilic gastroenteritis
food allergy, approach using restriction diet
central tolerance
killing of auto reactive T-cells and modification of auto reactive B cells before birth
rim pattern ANA
classic systemic lupus, anti ds DNA
homogeneous ANA
drug lupus
Speckled ANA
think anything
centromere pattern ANA
think CREST
nucleolar pattern ANA
think scleroderma
anti-dsDNA
sensitive and specific for systemic lupus, rim pattern on ANA
anti-ssDNA
drug-induced lupus
anti-histone
drug-induced lupus
anti-Sm
1/3 of systemic lupus, essentially makes the diagnosis
anti-Ro
Sjorgens
anti-La
Sjorgens
Anti-U1RNP
mixed connective tissue disease
anti-Scl70
scleroderma
anti-RNA polymerase III
scleroderma
anti-centromere
CREST (mild version of scleroderma)
anti-Jo
polymyositis/dermatomyositis
anti-Mi2
dernatomyositis
anti_SRP
sever polymyositis variant with severe necrotizing myopathy
anti-P155
Juvenile and paraneoplastic dermatomysitis
