Immunohematology

Question 1

Platelets are express and are

Answer 1

express a few antigens and are bathed in donor plasma

Question 2

Kell, Duff, Kidd and SsU

Answer 2

also implicated in hem trans rxn (esp delayed)

Question 3

<7

Answer 3

RBC transfuse

Question 4

> 10 + rapidly declining heme

Answer 4

RBC transfuse

Question 5

ICU and GI bleeds still have a heme tolerance of

Answer 5

7

Question 6

Fever + nonhemolytic rxn

Answer 6

normal vs, normal labs

Question 7

Fever + Hemolytic rxn

Answer 7

LDH, Haptoglobin

Question 8

Fever + Bacterial contamination

Answer 8

Lactate, blood cultures (consider culturing the donor blood)

Question 9

Fever + sepsis

Answer 9

see bacterial contamination, VS in septic shock

Question 10

Allergic Symptoms include…

Answer 10

volume overload = TACO
&
TRALI =abnormal vs and Leukopenia

Question 11

TRALI

Answer 11

Transfusion-associated Acute Lung Injury (similar to ARDS)

Question 12

TACO

Answer 12

Transfusion associated circulatory overload

Question 13

Content of FFP

Answer 13

Contains coagulation factors (as well as all other dissolved proteins, including antibodies)
Does NOT contain cells (with antigens)
NOT immunogenic.

Question 14

Indications for FFP

Answer 14

Urgent reversal of Warfarin.

Coagulopathy (as in DIC, Hemophilia) with INR>2 OR aPTT > 2x when specific factor concentrates are unavailable.

Question 15

Platelets have…

Answer 15

Cell fragments (but SOME ABO and HLA antigens present)
They DO NOT contain Rh antigens.
Considered to contain FFP in with the platelets…

Question 16

When giving platelets to someone…it’s always better to…

Answer 16

administer ABO compatible platelets…

but if that’s not possible, hemolytic rxn with non-ABO compatible pltlts are uncommon but possible

Question 17

ACS = transfuse if

Answer 17

<8g/dL

Question 18

Symptomatic and __ - __

Answer 18

7-10g/dL

Question 19

Cardiac Surgery if

Answer 19

7.5g/dL

Question 20

Non-cardiac surgery if

Answer 20

<8g/dL

Question 21

RBC t means the ____ blood cannot contain ANY antigens not present in the _____ body

Answer 21

donor’s……recipient’s

Question 22

FFP t means the ____ blood cannot contain ANY antigens not present in the _____ body

Answer 22

recipient’s…..donor’s

Question 23

Platelets contains ______ antigens AND antibodies

Answer 23

ABO

tricky matching, but major rxns are uncommon