Immunohema Module 2

Question 1

Also known as non-specific immunity

Answer 1

Innate or Natural Immunity

Question 2

Immunogens having a molecular weight (MW) less than 10,000 D

Answer 2

Haptens

Question 3

A complex protein produced by plasma
cells, with specificity to antigens, that
stimulate their production.

Answer 3

Antibodies

Question 4

Preferred in testing- highly specific, well
characterized, and uniformly reactive.

Answer 4

Monoclonal Ab

Question 5

Found in the
serum of
individuals who
have been
transfused or
who are
pregnant

Answer 5

Immune antibodies

Question 6

Immune antibodies are mostly Ig_ antibodies that react best at __ degrees celcius

Answer 6

IgG; 37 C

Question 7

Immune Ab requires the use of antihuman globulin sera for detection also known as _____.

Answer 7

Coomb’s sera

Question 8

Cold reacting Abs are:

Answer 8

P, I, Lewis, Mn

Question 9

Warm reacting Abs are:

Answer 9

Kell, Kidd, Duffy, Ss

Question 10

People with an immune
system that does not
function normally.

Some antibodies
require special
reagents to enhance
their reactivity and
detection

Answer 10

Unexpected antibodies

Question 11

Produced in response to
self-antigens

Answer 11

Autoantibodies

Question 12

Produced after exposure
to genetically different, or
non-self, antigens, (e.g.,
different RBC antigens
after transfusion)

Answer 12

Alloantibodies

Question 13

Capable of destroying transfused
antigen-positive RBCs, causing anemia
and transfusion reactions of various
severities.

Reacts at body temp.

Answer 13

IgG

Question 14

Most commonly encountered as naturally
occurring antibodies in the ABO system

Answer 14

IgM

Question 15

– ideal pH of a test system for antigen-antibody reactions

Answer 15

6.5-7.5

Question 16

Naturally occurring and react best at room temp.

Answer 16

Cold reacting Abs

Question 17

Destroyed by enzymes

Answer 17

MNSs
Duffy

Question 18

Enzyme-unaffected

Answer 18

Kell