Immunoglobulins

Question 1

What is an Immunoglobulin?

Answer 1

Antibody
Protein that contains Antigen binding sited

Question 2

Where are antibodies produced?

Answer 2

Plasma Cells which are produced by B Lymphocytes

Question 3

List the five classes of Immunoglobulins

Answer 3

IgM
IgG (4 subclasses)
IgA (2 subclasses)
IgE
IgD

Question 4

How do we refer to the bottom portion of an Antibody and what is it used for?

Answer 4

Fc (Fragment, Crystallized)
Determines class of Antibody
Ability for Placenta Passage
Interacts with Complement
Classical Pathway

Question 5

What is the most abundant Antibody found in blood plasma?

Answer 5

IgG
Monomer Structure (4 subclasses)
70%-75% of total Ig

Question 6

What is the function of IgG?

Answer 6

Acts on bacteria, fungi, and viruses
Ability to cross Placenta

Question 7

What is IgM and it’s function?

Answer 7

First responder to Antigenic stimuli
Produced by Underdeveloped Immune System of the Neonates

Question 8

What is IgA and where is it made?

Answer 8

Two subclasses
10% - 15% of total Serum Ig
Made by Plasma cells in the gut
Classified by Location (Serum/Secretory)

Question 9

What is the function of IgA?

Answer 9

Found in many body fluids
Secretory Unit: allows for transport across Mucosal Epithelium
Resistant to Enzyme Degradation

Question 10

What is most associated with Allergic and Anaphylactic Reactions?

Answer 10

IgE
Binds to Mast cells
Monomer structure

Question 11

What tends to be part of the IgM class?

Answer 11

Cryoglobulins

Question 12

Why do we care about Cryoglobulins?

Answer 12

Precipitate at lower than body temperature
Results in Vasculitis and Ischemic Injury