Immunodeficiency (Exam 2)

Question 1

Disorders in which a part of the body’s immune system is missing or dysfunctional.

Answer 1

Immunodeficiencies

Question 2

Inherited dysfunctions of the immune system.

Answer 2

Primary immunodeficiencies (PIDs)

Question 3

Acquired secondary to other conditions affecting the immune system

Answer 3

Secondary immunodeficiencies

Question 4

Name at least three possible causes of secondary immunodeficiency.

Answer 4

Malignancies, autoimmune disorders, infections, and immunosuppressive therapies

Question 5

What category of immunodeficiencies includes combined immunodeficiencies?

Answer 5

Category 1

Question 6

What category of immunodeficiencies includes complement deficiencies?

Answer 6

Category 8

Question 7

What category of immunodeficiencies includes congenital defects of phagocyte number, function, or both?

Answer 7

Category 5

Question 8

What category of immunodeficiencies includes predominantly antibody deficiencies?

Answer 8

Category 3

Question 9

What category of immunodeficiencies includes combined immunodeficiencies with associated or syndromic features?

Answer 9

Category 2

Question 10

A term meaning immunoglobulin deficiency?

Answer 10

Agammaglobulinemia

Question 11

Complete blood count (CBC) and white blood cell differentiation count are typically done to screen for which classification of immunodeficiency?

Answer 11

All immunodeficiencies

Question 12

Tests for serum IgG, IgA, IgM levels, IgG subclass levels, isohemagglutinin titers (IgM), and IgG response to proteins and polysaccharide antigens are typically done to screen for which classification of immunodeficiency?

Answer 12

Humoral immunity

Question 13

Delayed hypersensitivity skin tests, chest x-ray, and TREC screening are typically done to screen for which classification of immunodeficiency?

Answer 13

Cell-mediated immunity

Question 14

DHR reduction tests, and NBT dye tests are typically done to screen for which classification of immunodeficiency?

Answer 14

Phagocyte defect

Question 15

Tests for CH50 (classical pathway) and serum complement levels are typically done to screen for which classification of immunodeficiency?

Answer 15

Complement

Question 16

What kind of tests would be done to confirm the diagnosis of a humoral immunity disorder?

Answer 16

B-cell flow cytometry, B-cell proliferation, and histology of lymphoid tissues

Question 17

What kind of tests would be done to confirm the diagnosis of a cell-mediated immunity disorder?

Answer 17

T-cell flow cytometry, T-cell function, quantiferon TB assay, and enzyme assays

Question 18

What kind of tests would be done to confirm the diagnosis of a phagocytic defect disorder?

Answer 18

Leukocyte adhesion molecule analysis, phagocytic and bacterial killing assays, chemotaxis assays, and enzyme assays

Question 19

What kind of tests would be done to confirm the diagnosis of a complement disorder?

Answer 19

Specific component assays

Question 20

AH50 is an assay for…

Answer 20

Alternate pathway function

Question 21

DHR is an assay for…

Answer 21

neutrophil function (flow cytometry)

Question 22

Quantitative measurement of serum or urine immunoglobulins.

Answer 22

SPE (serum protein electrophoresis)

Question 23

Quantitative measurement of Ig, complement

Answer 23

Nephelometry

Question 24

What procedure can be done to evaluate monoclonal gammopathy or immunodeficiency?

Answer 24

Bone marrow aspiration and biopsy