Immunodeficiency

Question 1

Name 2 antibody deficiency PIDs.

Answer 1

Common variable immunodeficiency

Bruton’s disease

Question 2

Name a combine T/B cell PID.

Answer 2

SCID

Question 3

How does DiGeorge syndrome result in ID?

Answer 3

Thymine hypoplasia

Leading to T cell deficiency

Question 4

What will deficiency in the following complement proteins result in?

Answer 4

C3 - pyogenic infection
C5-C9 - Meningitis, sepsis and arthritis
C1 inhibitor - angiooedema

Question 5

What types of infections does deficiency in phagocytes result in?

Answer 5

Skin and mucous infections
Invasive fungal infection (aspergillosis)
Deep infections

Question 6

What types of infections will antibody deficiency result in?

Answer 6

Sinorespiratory infections
GI infections
Malignancies

Question 7

What type of infections are you prone if you have a T cell deficiency?

Answer 7

Deep skin and tissue
Oppurtunistic infections

(Death and failure to thrive if not treated)

Question 8

If immunodeficiency symptoms present at the following times what is the most likely PID type?

<6 months
6months - 5 years
5>

Answer 8

T cell/ phagocyte
B cell/ Ab
B cell/ Ab/ Complement / secondary ID