Immunodeficiency Flashcards
Any loss-of-function mutation affecting a ___ has negative consequences for survival.
TLR (Toll-like receptor)
What constitutes a primary immunodeficiency?
Due to genetic defects
What is secondary immunodeficiency?
Aquired due to malnutrition, cance, infection, etc.
Deficient _________ immunity usually results in increased susceptibility to infection by pyogenic bacteria.
Humoral
In XLA, what cells are affected and thus what type of immunodeficiency results?
B cells; humoral
Why would a patient with hyper-IgM constantly be producing IgM?
CD40 ligand loses function -> T cell does not costimulate B cells -> B cells only produce IgM rather than other
What is the treatment for humoral immunodeficiency?
- Prophylactic antibiotics
2. Gamma-globulin therapy
Deficient __________ immunity usually results in increased susceptibility to viruses and other intracellular pathogens.
Cell-mediated
DiGeorge’s syndrome is characterized by an underdeveloped thymus. Thus, __________ do not mature leading to ___________ immunodeficiency.
T cells; cell-mediated
What are the two goals of immunodeficiency treatments?
- Minimize and control infections
2. Replace defective part of immune system
In what types of cells are the majority of HIV found in the body?
CD4+ helper T cells
