Autoimmune Disease

Question 1

Which cells indicate the cell mediated response?

Answer 1

T cells

Question 2

Which cells indicate a humoral response?

Answer 2

B cells

Question 3

What is the major difference between T cells and B cells?

Answer 3

T cells recognize processed Ag with MHC - produce cytokines and release granules

B cells recognize free Ag via Ig receptor - Ig mediated destruction

Question 4

What are some factors that can predispose one to autoimmune disease?

Answer 4

1. Genetic
2. Women more than men
3. Chemical changes
4. Climate
5. Infectious agents
6. Immune dysregulation

Question 5

What initiates an autoimmune response?

Answer 5

1. Incomplete deletion of self reactive cells
2. Stimulation of normally anergic self reactive cells (microbe and self antigen simultaneously)
3. Altered regulation of anergic self reactive cells

Question 6

What are two ways that normally anergic self reactive T cells can become active?

Answer 6

1. APC reacts to microbe and self antigen simultaneously (microbe leads to costimulation)
2. Microbe creates mimic self-antigen on APC surface

Question 7

Which autoimmune diseases are systemic?

Answer 7

1. SLE

2. Rheumatoid Arthritis

Question 8

Which autoimmune diseases are organ specific?

Answer 8

1. IDDM

2. MS

Question 9

Loss of which type of tolerance would likely result in a systemic autoimmune disease?

Answer 9

Central tolerance