Immuno6 Flashcards
Cytokines
What cytokines are secreted by macrophages?
IL-1 IL-6 IL-8 IL-12 TNF-a
What cytokines are secreted by ALL T cells?
IL-2
IL-3
What cytokines are secreted by Th1 cells?
Interferon-gamma
What cytokines are secreted by Th2 cells?
IL-4
IL-5
IL-10
also IL-6
IL-1
- Fever & Acute Inflammation
- Activats endothelium to express adhesion molecules
- Induces chemokine secretion to recruit leukocytes
IL-6
- Fever
- Stimulates production of acute-phase proteins
IL-8
MAJOR CHEMOTACTIC FOR NEUTROPHILS
“Clean up on aisle 8”
IL-12
- Induces differentiation of T els into Th1 cells
- Secreted by Macrophages and B cells
TNF-a
- Septic Shock mediator
- Activates endothelium
- Causes leukocyte recruitment, vascular leak
IL-2
-Stimulates growth of helper, cytotoxic, and regulatory T-cells
IL-3
- Supports growth and differentiation of bone marrow stem cells
- Functions like GM-CSF
Interferon-gamma
- Activates Macrophages and Th1 cells
- Suppresses Th2 cells
- AntiViral & AntiTumor properties
IL-4
- Induces differentiation into Th2 cells
- Promotes growth of B-cells
- Enhances class switching to IgE & IgG
IL-5
- Promotes differentiation of B cells
- Enchances class switching to IgA
- Stimulates growth and differentiation of Eosinophils
IL-10
- Modulates inflammatory response
- Inhibits actions of activated T-cells and Th1
- Secreted by Th2 and Tregs
What other cytokine has similar properties of IL-10?
TGF-ß
Induces chemokine secretion to recuit leukocytes.
IL-1
Functions like GM-CSF.
IL-3
Suppresses Th2 cells.
Interferon-gamma
Enhances class switching to IgE and IgG.
IL-4
Stimulates production of acute-phase proteins.
IL-6
Inhibits actions of activated T-cells and Th1.
IL-10 & TGF-ß
Enhances class switching to IgA.
IL-5
Activates NK cells.
IL-12
Major chemotactic factor for neutrophils.
IL-8
Mnemonic for IL1-IL5 functions.
"Hot T-Bone stEAk" IL-1: Fever (hot) IL-2: stimulates T cells IL-3: stimulates Bone marrow IL-4: stimulates IgE production IL-5: stimulates IgA production
What is the function of Interferons (alpha, beta, gamma)?
-Place uninfected cells in an AntiViral state
Interferons MOA.
-Induce production of a ribonuclease that inhibits viral protein synthesis by degrading mRNA
What Interferons inhibit viral protein synthesis?
alpha & beta
What does Interferon-gamma do to fight off viruses?
INcrease MHC I and MHC II expression and antigen presentation in ALL cells
