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FA - Immunology > Immuno6 > Flashcards

Immuno6 Flashcards

Cytokines

1
Q

What cytokines are secreted by macrophages?

A 
IL-1
IL-6
IL-8
IL-12
TNF-a
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2
Q

What cytokines are secreted by ALL T cells?

A

IL-2

IL-3

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3
Q

What cytokines are secreted by Th1 cells?

A

Interferon-gamma

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4
Q

What cytokines are secreted by Th2 cells?

A

IL-4
IL-5
IL-10
also IL-6

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5
Q

IL-1

A
  • Fever & Acute Inflammation
  • Activats endothelium to express adhesion molecules
  • Induces chemokine secretion to recruit leukocytes
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6
Q

IL-6

A
  • Fever

- Stimulates production of acute-phase proteins

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7
Q

IL-8

A

MAJOR CHEMOTACTIC FOR NEUTROPHILS

“Clean up on aisle 8”

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8
Q

IL-12

A
  • Induces differentiation of T els into Th1 cells

- Secreted by Macrophages and B cells

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9
Q

TNF-a

A
  • Septic Shock mediator
  • Activates endothelium
  • Causes leukocyte recruitment, vascular leak
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10
Q

IL-2

A

-Stimulates growth of helper, cytotoxic, and regulatory T-cells

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11
Q

IL-3

A
  • Supports growth and differentiation of bone marrow stem cells
  • Functions like GM-CSF
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12
Q

Interferon-gamma

A
  • Activates Macrophages and Th1 cells
  • Suppresses Th2 cells
  • AntiViral & AntiTumor properties
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13
Q

IL-4

A
  • Induces differentiation into Th2 cells
  • Promotes growth of B-cells
  • Enhances class switching to IgE & IgG
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14
Q

IL-5

A
  • Promotes differentiation of B cells
  • Enchances class switching to IgA
  • Stimulates growth and differentiation of Eosinophils
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15
Q

IL-10

A
  • Modulates inflammatory response
  • Inhibits actions of activated T-cells and Th1
  • Secreted by Th2 and Tregs
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16
Q

What other cytokine has similar properties of IL-10?

A

TGF-ß

17
Q

Induces chemokine secretion to recuit leukocytes.

A

IL-1

18
Q

Functions like GM-CSF.

A

IL-3

19
Q

Suppresses Th2 cells.

A

Interferon-gamma

20
Q

Enhances class switching to IgE and IgG.

A

IL-4

21
Q

Stimulates production of acute-phase proteins.

A

IL-6

22
Q

Inhibits actions of activated T-cells and Th1.

A

IL-10 & TGF-ß

23
Q

Enhances class switching to IgA.

A

IL-5

24
Q

Activates NK cells.

A

IL-12

25
Q

Major chemotactic factor for neutrophils.

A

IL-8

26
Q

Mnemonic for IL1-IL5 functions.

A 
"Hot T-Bone stEAk"
IL-1: Fever (hot)
IL-2: stimulates T cells
IL-3: stimulates Bone marrow
IL-4: stimulates IgE production
IL-5: stimulates IgA production
27
Q

What is the function of Interferons (alpha, beta, gamma)?

A

-Place uninfected cells in an AntiViral state

28
Q

Interferons MOA.

A

-Induce production of a ribonuclease that inhibits viral protein synthesis by degrading mRNA

29
Q

What Interferons inhibit viral protein synthesis?

A

alpha & beta

30
Q

What does Interferon-gamma do to fight off viruses?

A

INcrease MHC I and MHC II expression and antigen presentation in ALL cells

FA - Immunology (12 decks)

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