Immuno5

Question 1

Complement protects against what type of pathogens?

Answer 1

Gram-NEGATIVE bacteria

Question 2

What are the 3 activation pathways of complement?

Answer 2

Classic pathway
ALternative pathway
Lectin pathway

Question 3

What mediates the Classic pathway?

Answer 3

IgG or IgM

Question 4

What mediates the Alternative pathway?

Answer 4

Microbe surface molecules

Question 5

What mediates the Lectin pathway?

Answer 5

Mannose or other sugars on microbe surface

Question 6

Function of C3b. (2)

Answer 6

Opsonization

helps clear Immune complexes

Question 7

Function of C3a.

Answer 7

Anaphylaxis

Question 8

Functions of C5a. (2)

Answer 8

Anaphylaxis

Neutrophil chemotaxis

Question 9

Function of C5b-C9.

Answer 9

Cytolysis by MAC (membrane attack complex)

Question 10

What are the 2 primary opsonins in bacterial defense?

Answer 10

C3b & IgG

Question 11

What inhibitors help prevent comlement activation on self cells (e.g., RBC)?

Answer 11

DAF (Decay-Accelerating Factor)

C1 Esterase Inhibitor

Question 12

Complement Disorder:

- C1 esterase inhibitor deficiency

Answer 12

Hereditary Angioedema

*Do NOT give ACE inhibitors (contraindicated)

Question 13

Complement Disorder:

- C3 deficiency

Answer 13

• Severe, recurrent pyogenic sinus and respiratory tract infections
• Increased susceptibility to type III hypersensitivity reactions

Question 14

Complement Disorder:

- C5-C8 deficiency

Answer 14

Recurrent Neisseria bacteremia

Question 15

Complement Disorder:

- DAF (GPI anchored enzyme) deficiency

Answer 15

Complement-mediated lysis of RBCs and Paroxysmal Nocturnal Hemoblobinuria (PNH)