Immuno. III - Week 4 (Kidney Disease)

Question 1

What is Goodpasture syndrome also known as?

Answer 1

anti-GBM disease

Question 2

Describe the pathogenesis of Goodpasture’s syndrome?

Answer 2

Antibodies attack the basement membrane in the kidneys and/or lungs.
White blood cells activated and attack vessel wall leading to glomerulonephritis, lungs, and kidney failure.

Question 3

What does Goodpasture’s syndrome biopsy look like?

Answer 3

Red cells in urine and abnormal crescent-shaped cells

Bright green colour of anti-GBM through immunofluorescent microscopy