Immuno, III- Week 4 (Hepatology)

Question 1

Name the three categories of autoimmune liver disease

Answer 1

Autoimmune Hepatitis (AIH)
Primary Biliary Cirrhosis (PBC)
Primary Sclerosing Cholangitis (PSC)

Question 2

Define Primary Biliary Cholangitis (PBC)

Answer 2

Chronic condition in which inflammation causes scarring of both intrahepatic bile ducts

Question 3

Define Primary Sclerosing Cholangitis (PSC)

Answer 3

Condition that affects both the intrahepatic and extrahepatic structures.

Question 4

What is the consequence to the liver in Primary Billiary Cholangitis?

Answer 4

Bile duct damage, liver tissue scarring then liver failure

Question 5

What is the pathogenesis of Primary Biliary Cholangitis

Answer 5

initiated through molecular mimicry due to breakdown in tolerance.
T-cell mediated injury that damages biliary epithelial cells. Fibrosis forms in the intrahepatic bile ducts

Question 6

What are the symptoms of Primary Sclerosing Cholangitis?

Answer 6

Fatigue
Abdomen pain
Itching
Jaundice
Chronic right upper right quadrant pain

Question 7

what is the common outcome of primary sclerosing cholangitis?

Answer 7

Vitamin deficiency

Question 8

What is the pathogenesis of Primary Sclerosing Cholangitis

Answer 8

T cells attacking bile duct epithelial tissue, causing inflammation.
Cholangiocyte cells die, leading to fibrosis with a bead appearance

Question 9

What are autoimmune liver diseases diagnosed?

Answer 9

Clinical findings
Histological abnormalities
Elevated serum aspartate aminotransferase
Elevated alanine aminotransferase
IgG serum increase
presence of one or more characteristic autoantibodies

Question 10

what autoantibodies are found in Primary Biliary Cholangitis

Answer 10

Anti-AMA, AMA-M2, gp210

Question 11

what autoantibodies are found in Primary Sclerosing Cholangitis

Answer 11

anti-p-ANCA