Immuno Drugs Flashcards
Cyclosporine: MOA? Use? Toxicity?
1) Blocks calcineurin (which usually activates IL-2)
2) Organ transplant and some autoimmune disorders
3) Nephrotoxicity and hypertension, hirsutism, tremor, GINGIVAL HYPERPLASIA
Patient with a recent liver transplant uses drug that causes her to grow her on her chin, develops tremor, and her BUN and creatinine both rise
Cyclosporine– blocks calcineurin which inhibits IL2 (could be tacrolimus if it didn’t cause hirsutism)
Tacrolimus: MOA? Use? Toxicity?
1) Binds FK binding proteins inhibiting calcineurin
2) Organ transplants
3) Nephrotoxicity, hypertension, tremor NO GINGIVAL HYPERPLASIA OR HIRSUTISM
Sirolimus: MOA? Use? Toxicity?
1) Inhibits mTOR
2) Immunosuppression after kidney transplant; used in combo with cyclosporin and corticosteroids
3) Hyperlipidemia; thrombocytopenia, leukopenia
Drug to use for patient after kidney transplant? Side effects to monitor?
1) Sirolimus
2) Leukopenia, and thrombocytopenia
Azathioprine: MOA? Use? Toxicity?
1) Antimetabolite precursor of 6MP; toxic to proliferating lymphocytes
2) Kidney transplantation, autoimmune disorders
3) Active metabolite is degraded by xanthine oxidase so allopurinol may worse effects
Patient about to start 6MP, which medication should she also be on? Which medication is contraindicated?
1) Azothioprine
2) Allopurinol since active metabolite of 6MP is degraded by xanthine oxidase
Muromonab: MOA? Use? Toxicity?
1) Binds CD3
2) Immunosuppression after kidney transplant
3) Cytokine release syndrome; hypersensitivity reaction
Patient received drug after kidney transplant. Begins to have hypotension, fever, and shivering
Muromonab– toxicity is cytokine release syndrome
Drug for MS?
Beta interferon
HER2 target?
Trastuzumab
Rituximab?
CD20 target; non-hodgkins lymphoma
MOA of corticosteroids?
Inhibit NF-kappa B
