Immuno BB Flashcards
A 30 year old women presents to her GP with a red, itchy, oozing rash around her neck and fingers
contact dermatitis
A 55 year old man with history of angina was advised to take a tablet before a long flight. After taking the pill, he suddenly finds that he has difficulty breathing, feels nauseous and is itching.
mast cell degranulation
A 24 year old medical student develops worsening swelling of the hands and feet and abdominal pain before her final year medical exams. She says that similar milder episodes have occurred preciously.
c1 inhibitor deficiency
A 35 year old woman presents with persistent itchy wheels for the last 2 months. She noticed that when this is at its worst, she also has a fever and feels generally unwell. After an acute attack, she has bruising and post-inflammatory residual pigmentation at the site of the itching.
urticarial vasculitis
A 35 year old woman presents with a two day history of a red itchy skin rash which started soon after her first scuba-diving lesson. She is otherwise well.
acute urticaria
A 22 year old woman presents with an intermittently itchy and desquamating skin rash on her abdomen which is unresponsive to antihistamines
contact hypersensitivity
This 45 year old woman presents to A&E with tongue swelling and acute respiratory tract obstruction. She has longstanding hypertension and received a renal transplant two years previously. no allergic Hx, examination normal
acute angioedema
Rx for allergic rhinitis
PO antihistamines
MHC associated with Th1 cells
MHC class 2
Which component of the innate immune system is usually one of the first to respond to infection through a cut?
neutrophil
Commonest infection as a result of B cell deficiency
bacterial
Meningococcal infections are quite common as a result of which deficiency of the component of the immune system?
complement
What is the functional complement test used to investigate the classical pathway?
CH50
Which complement factor is an important chemotaxic agent?
c3a
Classification of autoimmune diseases
Type II - antibody mediated - Graves' disease - ITP - ABO incompatibility transfusion reaction - Goodpasture's disease - myesthenia gravis Type III - immune complex mediated - SLE - Hep C associated membranoprolypherative glomerulonephritis type 1 Type IV - T cell mediated - Rheumatoid arthritis - T1DM
Goodpastures: The pattern of the antibody deposition in the glomerular basement membrane is typically described as what?
smooth, linear
Goodpastures: Immune damage may be associated with the kidney and commonly which other tissue?
Lung
Severe Combined Immunodeficiency. which protein affected
IL-2 receptor
This region encodes C2, C4 and factor B
MHC class III
In acute rejection, release of this substance from CD8+ lymphocytes helps kill target cells
Granzyme B
In acute rejection, these are produced as a result of the activation of neutrophils and macrophages
Free radicals
Risk factor for chronic allograft rejection
hypertension
The 3 most important HLA types to screen for in renal transplantation when matching donor and recipient, in order of importance
HLA DR > B > A
Prevents DNA replication especially of T cells
mycophenylate mofetil
Causes a transient increase in neutrophil count
prednisolone
Monoclonal antibodies inhibiting the actions of cytokines
infliximab
Plasmapheresis may be indicated in which condition?
Goodpasture’s
A condition where antigen desensitization therapy may be indicated
bee/wasp venom allergy
Administration of this may boost the immune system
immunoglobulins
Prednisolone side effect
hypertension
cyclosporin side effect
HTN and reduced GFR
azathioprin side effect
bone marrow suppression
methotrexate side effect
pneumonitis, pulmonary fibrosis, cirrhosis
immunoglobulin side effect
anaphylaxis
Vaccine that is made using recombinant DNA technology.
Hep B vaccine
A vaccine given only to sero-negative women
Rubella
A feature of immunological central memory
IL2
Which vaccine is normally given to infants under the age of 13 months in the form of three doses at monthly intervals to protect against an infection that has symptoms similar to meningitis and predominantly occurs in children < 5 years?
HiB
Diploid cell vaccine containing inactivated virus given before or after exposure to those considered at risk.
rabies
Live attenuated vaccine that is no longer given as standard in the UK since the rates of reverse mutation are higher than those of active disease.
polio (sabin)
A conjugate vaccine
HiB
Excreted in the stools of immunised individuals.
oral poliomyelitis vaccine
