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GI Midterm > Immuno > Flashcards

Immuno Flashcards

1
Q

What T helper cells are involved in inflammation/Chron’s disease?

A

Th1 + Th17

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2
Q

What type of T cells are involved in homeostasis/Tolerance?

A

Treg and TGFB

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3
Q

What type of T cells are involved in allergy/adverse food reactions?

A

Th2

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4
Q

What cells produce antimicrobial peptides?

A

Epithelial cells (AMP upregulated by Th17)

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5
Q

What stimulates the production of mucus plus IgA response to foreign gut pathogens?

A

SCFAs

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6
Q

What 3 things are critical for oral tolerance (Tregs)?

A

TGF-B, Retinoic Acid, IDO (CD4+ cells)

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7
Q

Tregs produce…

A

IL-10 and TGFB and they inhibit Th2

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8
Q

What 2 things increase vascular permeability + smooth muscle contractility + trigger distal reactions?

A

Histamine + PAF

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9
Q

This enzyme acts on C3 and C5 to produce C3a + C5a and exacerbate symptoms.

A

Typtase

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10
Q

What is the main tool for assessing hypersensitivity reactions?

A

History

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11
Q

Type IV hyperesentivity = ______

A

delayed + T cell mediated

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12
Q

Cow milk + Peanut allergies are unique in that they can be both:

A

IgE and non-IgE

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13
Q

What is the main genetic predisposing factor for celieac disease?

A

HLA-DQ2 (95%) + DQ8

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14
Q

What do you test for celiac disease?

A

Total IgA

(test for IgA antibody to transglutaminase)

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15
Q

What deanimates glutamine making it into glutamic acid?

A

TG2

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16
Q

TG2 is a risk facto for what type of disease?

A

Autoimmune disease

17
Q

IgA causes what type of response?

A

Chronic inflammatory response

18
Q

What cytokine do Th2 cells secrete to get IgA (B cells)

A

IL-5

19
Q

What cytokine do Th2 cells secrete to get IgE (B cells)?

A

IL-4

(EDIE = 4 letters)

20
Q

What two hormones make up an acute local reaction in the GI?

A

Seratonin + PAF

21
Q
A

GI Midterm (8 decks)

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