Immunity And Infection Flashcards
What are the three lines of defence in the body’s defence mechanisms?
1st line: Skin and Mucous membranes
2nd line: Inflammation
3rd line: Immunity
Define infection.
An extension of inflammatory and immune processes
What is the role of CD8 T Cells in cell mediated immunity?
Release perforin (MAC) and lymphotoxin (DNA) for autolysis and apoptosis
What are the components of the immune system?
Bone Marrow, Thymus Gland, Lymph Nodes, Spleen/Tonsils
How do B Cells contribute to humoral immunity?
B Cells mature into plasma cells in bone marrow and produce immunoglobulin
What is the function of CD4 T Cells?
Manage and coordinate the immune response, activate CD8 cells and B cells
Fill in the blank: The _______ is a disease-producing micro-organism.
[Pathogen]
List the phases of acute infection clinical manifestations.
- Pain
- Heat
- Redness
- Swelling
- Lymphadenopathy
- Loss of function
- Purulent exudate
- Fever
- Malaise
- Weakness
- Anorexia
- Headache
- Nausea
True or False: Resident flora are microorganisms that cause harm to the body.
False
What are the types of immunity?
- Cell mediated immunity
- Humoral immunity
What is the role of plasma cells?
Produce immunoglobulin that interact with specific antigens
What are some laboratory and diagnostic tests for infection?
- White blood cell count
- Serum antibody levels
- Cultures
- Sensitivities
Fill in the blank: Infection is a complication of _______.
[immune function]
What are the actions of antibodies (immunoglobulin)?
- Agglutination
- Precipitation
- Neutralisation
- Lysis
- Opsonisation
- Activation of complement cascade
What is the definition of infectious disease?
A state of tissue destruction resulting from invasion by micro-organisms
What does the inflammatory response signify in the body’s defence?
2nd line of defence
What do memory cells do in the immune response?
Both cell mediated and humoral immunity processes produce memory cells
