Immunity And Infection Flashcards
What are the three lines of defence in the body’s defence mechanisms?
1st line: Skin and Mucous membranes
2nd line: Inflammation
3rd line: Immunity
Define infection.
An extension of inflammatory and immune processes
What is the role of CD8 T Cells in cell mediated immunity?
Release perforin (MAC) and lymphotoxin (DNA) for autolysis and apoptosis
What are the components of the immune system?
Bone Marrow, Thymus Gland, Lymph Nodes, Spleen/Tonsils
How do B Cells contribute to humoral immunity?
B Cells mature into plasma cells in bone marrow and produce immunoglobulin
What is the function of CD4 T Cells?
Manage and coordinate the immune response, activate CD8 cells and B cells
Fill in the blank: The _______ is a disease-producing micro-organism.
[Pathogen]
List the phases of acute infection clinical manifestations.
- Pain
- Heat
- Redness
- Swelling
- Lymphadenopathy
- Loss of function
- Purulent exudate
- Fever
- Malaise
- Weakness
- Anorexia
- Headache
- Nausea
True or False: Resident flora are microorganisms that cause harm to the body.
False
What are the types of immunity?
- Cell mediated immunity
- Humoral immunity
What is the role of plasma cells?
Produce immunoglobulin that interact with specific antigens
What are some laboratory and diagnostic tests for infection?
- White blood cell count
- Serum antibody levels
- Cultures
- Sensitivities
Fill in the blank: Infection is a complication of _______.
[immune function]
What are the actions of antibodies (immunoglobulin)?
- Agglutination
- Precipitation
- Neutralisation
- Lysis
- Opsonisation
- Activation of complement cascade
What is the definition of infectious disease?
A state of tissue destruction resulting from invasion by micro-organisms
