Immune thrombocytopenic purpura Flashcards
1
Q
What is immune thrombocytopenic purpura?
A
An autoimmune condition characterised by a reduction in the number of circulating platelets
2
Q
What type of hypersensitivity reaction is TTP?
A
Type 2 hypersensitivity reaction
3
Q
What is the pathophysiology of TTP?
A
The spleen produces antibodies to glycoprotein IIb/IIIa
4
Q
What is the most common cause of ITP?
A
Viral infection
Following immunisation
5
Q
What is the presentation of ITP?
A
Bruising
Petechiae
Prolonged bleeding from cuts
Spontaneous bleeding from gums or nose
Blood in urine or stools
Menorrhagia
6
Q
What investigations are used in the diagnosis of ITP?
A
FBC - isolated thrombocytopenia
Blood film
Inflammatory markers
7
Q
What is the first line management of ITP?
A
Oral prednisolone
8
Q
What is the second line management of ITP?
A
IVIg
