Hodgkin Lymphoma Flashcards
What is hodgkin lymphoma?
Lymphoma is a cancer affecting the lymphocytes of the lymphatic system
What is the age distribution of patients with Hodgkin lymphoma?
Bimodal - 15-35 years and >60 years
What are the risk factors for Hodgkin lymphoma?
HIV
EBV
Family history
Autoimmune disorders
What are the symptoms of Hodgkin lymphoma?
Painless lymphadenopathy
B symtpoms:
- Fever
- Weight loss
- Night sweats
Alcohol induced lymph node pain
Pruritus
What initial investigations are performed in suspected Hodgkin lymphoma?
FBC - leukocytosis
LDH - elevated
Ultrasound of lymph nodes
What investigation is diagnostic of Hodgkin lymphoma?
Excisional lymph node biopsy
What cells are seen in Hodgkin lymphoma but not non-hodgkin lymphoma?
Reed-Sternberg cells
What is the ann-arbor staging of hodgkin lymphoma?
Stage 1 - single lymph node
Stage 2 - Two or more lymph nodes on the same side of the diagphragm
Stage 3 - lymph nodes on both sides of the diaphragm
Stage 4 - involvement of one or more extralymphatic organs
A - no systemic symptoms
B - B symptoms present
What is the management of hodgkin lymphoma?
Chemotherpy
Radiotherapy (often administered after chemo - called combined modality therapy)
What regimens of chemotherapy are commonly used for hodgkin lymphoma?
ABVD - doxorubicin, bleomycin, vinblastine and dacarbazine
BEACOPP - bleomycin, etoposide, adriamycin, cyclophosphamide, oncovin, procarbazine, prednisolone
What are the complications of hodgkin lymphoma treatment?
Myelosuppression
Neutropenic sepsis
Tumour lysis syndrome
