Non-hodgkin lymphoma

Question 1

What are the risk factors for non-hodgkin lymphoma?

Answer 1

> 50 years
Male
HIV
EBV
H. Pylori - associated with MALT lymphoma
Autoimmune conditions - Hashimoto’s and Sjogren’s

Question 2

What are the symptoms of non-hodgkin lymphoma?

Answer 2

B symptoms
- Fever
- Weight loss
- Night sweats
Painless lymphadenopathy
Splenomegaly - more common in NHL compared to HL

Question 3

What initial investigations can be performed in suspected NHL?

Answer 3

FBC - leukocytosis
Blood film
LDH and uric acid - raised
Ultrasound of lymph nodes

Question 4

What is the diagnostic investigation for NHL?

Answer 4

Excisional lymph node biopsy

Question 5

What is the management of NHL?

Answer 5

Low grade B cell lymphoma
- Radiotherapy
High grade B cell lymphoma
- Chemotherapy

Question 6

What chemotherapy regimes are often used in the treatment of NHL?

Answer 6

R-CHOP
- Rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone
R-CVP
- Rituximab, cyclophosphamide, vincristine, prednisolone
RCODOX-M
- Rituximab, cyclophosphamide, doxorubicin, vincristine, methotrexate q