Immune System - OpenStax Chapter 42 Flashcards
Read first 64 pages Mean Genes
…Progress…
Human immune system many parts
- Physical Barriers - Innate immune system - Adaptive immune system
2 trillion cells
Non-self molecules include those from; -bacteria INCOMPLETE
Physical and chemical barriers
- Unbroken skin - mucus membranes - earwax - cilia (pushing stuff out of respiratory tract) - stomach acid
cells of the immune system
————stem cell—————– INCOMPLETE
innate immune system
inflamation INCOMPLETE
Inflammation makes the area inhospitable
attracts macrophages (wbc) to engulf bacteria plasma accumulates (swelling)to dilute toxins increased blood flow increases temperatures (redness)
complement and cytokines are
proteins secreted by immune sytem cells
complement and cytokines are
proteins secreted by immune sytem cells
Complement proteins
plasma proteins that attract phagocytes and destroy bacterial plasma membranes, trigger mast cells to degranulate
cytokines proteins
interferons: alert other components of immune system to viral infections interlukins - cause fever and decrease iron in blood, invigorate phagocytes
Innate vs Adaptive immune system
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adaptive immune system is diverse, specific and remembers
* Needs to be stimulated - Antigens - Cytokines - Primary immune response - needs to learn an antigen - Secondary immune response - faster response (memory cells)
antibodies are part of the adaptive immune response
Macropage (cell) presents antigen (target) to activate T cell INCOMPLETE
Summary of immune system
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Types of antibodies
- Immune system makes polyclonal antibodies… INCOMPLETE
Antibody
photomada…
how can your genes make antibodies that recognize almost any antigen?
antibody genes regions V ariable D iversity J oining C onstant photo
The thymus weeds out antibodies that recognize self antigens (targets)
- Immature T cells enter the thymus - If they recognize a “self”… INCOMPLETE
Vaccines have been around for a long time
- China, 11 century, used powdered smallpox scabs - Observed by British in 1796 - Edward Jenner modified it - used cowpox instead of smallpox - Smallpox eradicated from the wild in 1977
Vaccines activate the adaptive immune system
- inactive or weakened pathogen * pathogen is the organism that makes you sick - Stimulates the primary immune response * B cells start making antibodies and memory cells If infected later, will stimulate secondary immune response * memory cells… INCOMPLETE
Why does my choice matter to others?
“When most of the population is immunized spread of the disease is constrained”
why do you need a flu shot each year?
* Capsid - protein shell * Lipid envelope - remains of plasma membrane of cell that made the virus * Hemagglutinin - “Key” that binds receptor on cell - 17 kinds known * Neuraminidase - Enzyme (cuts virus away from receptor of infected cell) - 9 kinds known * Name flue strain by proteins, i.e. H1N5 - Always many varieties of flu circulating
Influenza is:
an RNA virus
