IMMUNE SYSTEM & MALIGNANT DISEASE Flashcards
AZATHIOPRINE
How does it work?
Antimetabolite-> breaks down into mercaptopurine which inhibits the reimpairment+making of DNA
AZATHIOPRINE
PRE-TREATMENT SCREENING?
CHECK TPMT LEVELS as TPMT metabolises thiopurine drugs (azathiopurine, mercaptopurine & tioguanine)
Reduced activity of enzyme? risk of myelosuppression
AZATHIOPRINE- SIDE-EFFECTS? HN^2T
HN^2T
HYPERSENSITIVITY-> malaise/dizziness/D+V/fever
NEUTROPENIA/THROMBOCYTOPENIA-> sore throat/bruising/bleeding
NAUSEA-> common at start, resolves over time
TERATOGENIC-> avoid in pregnancy
AZATHIOPRINE- MONITORING REQUIREMENTS?
TPMT
REGULAR LFT/FBC, more often in liver/renal impairment
FBC weekly for first 4 weeks, then at least /3 months
AZATHIOPRINE- INTERACTIONS?
AZATHIOPRINE+ALLOPURINOL? haematological toxicity-> reduce AZA dose to 1/4 of usual dose
AZATHIOPRINE+ACE-i? anaemia/leucopenia-> AVOID concomitant use
CALCINEURIN INHIBITORS- Examples?
Ciclosporin
Tacrolimus
CICLOSPORIN/TACROLIMUS
How does it work?
inhibits lymphokines-> suppresses cell-mediated response
CICLOSPORIN/TACROLIMUS- MHRA WARNING?
PRESCRIBE AND DISPENSE BY BRAND NAME ONLY
CICLOSPORIN- SIDE-EFFECTS?
bit longer start
HYPER- glycaemia/uricemia/kalaemia/lipidaemia/tension HYPO- magnesaemia Renal/Liver Impairment Skin Reactions Gingival Hyperplasia Hair changes (hirsutism) Eye inflammation/vision Ls (topical)
CICLOSPORIN/TACROLIMUS- AVOID IN..?
PREGNANCY
BREAST-FEEDING
malignancy
uncontrolled hypertension/infections
CICLOSPORIN- INTERACTIONS
Increases exposure? GPOM
Decreases exposure? PG
Can mix with?
GRAPEFRUIT+POMELO juice-> increased ciclosporin exposure
PURPLE GRAPE JUICE-> decreased ciclosporin exposure
BUT…
Can mix with orange/apple juice to improve taste
CICLOSPORIN- PRE-SCREENING?
Exclude malignancies obvs
CICLOSPORIN- MONITORING & ADVICE?
Cameron Loves Money | Polly Loves Chanel Bags Ciclosporin trough levels LFT Magnesium Potassium Lipids CrCl Blood Pressure
AVOID EXPOSURE TO UV/SUNLIGHT
TOPICAL? can affect driving/skilled etc
TACROLIMUS- SIDE-EFFECTS?
HYPER-glycaemia+uricaemia/kalaemia HYPO/HYPERtension RENAL/LIVER IMPAIRMENT SKIN REACTIONS VISUAL DISTURBANCES BLOOD DYSCRASIA CVD (QT prolongation/cardiomyopathy in children) Nervous system disorder/peripheral neuropathy
LEARN CICLO/TACRO TOGETHER!
SIMILAR/DIFFERENCES
TACROLIMUS- INTERACTIONS? GP^2
Patient has hypersensitivity to macrolide?
GRAPEFRUIT/POMEGRANATE/POMELO juice- INCREASES tacrolimus levels
Patient has hypersensitivity to macrolide? DO NOT USE
TACROLIMUS- MONITORING & ADVICE?
Bob and Eve Baked Lovely Egg Cakes Blood pressure ECG Blood glucose LFT Electrolytes CrCL
AVOID EXPOSURE TO UV/sunlight
Driving/skilled L
MYCOPHENOLATE MOFETIL
How does it work?
Inhibits purine synthesis
MYCOPHENOLATE MOFETIL- RISKY SIDE-EFFECTS?
BONE MARROW SUPPRESSION->report infection/bruising/bleeding
PURE RED CELL APLASIA-> reduce dose/discontinue
HYPOGAMMAGLOBULINAEMIA-> measure immunoglobulin levels in recurrent infection
BRONCHIECTASIS-> persistent cough/SOB develops
MYCOPHENOLATE MOFETIL- MHRA CONTRACEPTION ADVICE (TERATOGENIC)
WOMEN?
MEN?
WOMEN? 1 effective contraceptive before+during+6 weeks after treatment (2 methods preferred)
MEN? during treatment+90 days after-> OR female partner
MULTIPLE SCLEROSIS
What is it?
Chronic autoimmune disease demyelinating the CNS
MULTIPLE SCLEROSIS
Can be relapsing/progressive/both
Active disease?
At least 2 big relapses in the past 2 years, despite interferon beta treatment