Immune system Cells Flashcards
Helper T cells function
Involved in the cell-mediated immune response
Recognises antigens presented by MHC class II molecules
Expresses CD4
Also expresses CD3, TCR & CD28
Major source of IL-2
Mediates acute and chronic organ rejection
Cytotoxic T cells function
Involved in the cell-mediated immune response
Recognises antigens presented by MHC class I molecules
Induce apoptosis in virally infected and tumour cells
Expresses CD8
Also expresses CD3, TCR
Mediates acute and chronic organ rejection
B cells function
Major cell of the humoral immune response
Acts as an antigen presenting cell
Mediates hyperacute organ rejection
Plasma cells function
Differentiated from B cells
Produces large amounts of antibody specific to a particular antigen
Neutrophil function
Primary phagocytic cell in acute inflammation
Granules contain myeloperoxidase and lysozyme
neutrophil structure
Multi-lobed nucleus
Basophil
Releases histamine during allergic response
Granules contain histamine and heparin
Expresses IgE receptors on the cell surface
Basophil structure
Bi-lobed nucleus
Mast cell properties
Present in tissues and are similar in function to basophils but derived from different cell lines
Releases histamine during allergic response
Granules contain histamine and heparin
Expresses IgE receptors on the cell surface
Eosinophil function
Defends against protozoan and helminthic infections
Monocyte function
Diffferentiates into macrophages
Macrophage function
Involved in phagocytosis of cellular debris and pathogens
Acts as an antigen presenting cell
Major source of IL-1
Natural killer cell function
Induce apoptosis in virally infected and tumour cells
Dendritic cell function
Acts as an antigen presenting cell
