Cytokines (interleukins) Flashcards
IL-1 main sources
Macrophages
function of IL-1
induces fever
IL-2 main source
T helper 1 cells
function of IL2
Stimulates growth and differentiation of T cell response
IL-3 main source
Activated T helper cells
IL-3 function
Stimulates differentiation and proliferation of myeloid progenitor cells
IL-4 main source
T-H2 cells
IL-4 function
Stimulates proliferation and differentiation of B cells
IL-5 main source
Th2 cells
IL-5 function
Stimulate production of eosinophils
IL-6 main source
Macrophages, Th2 cells
IL-6 function
Stimulates differentiation of B cells
Induces fever
IL-8 main source
Macrophages
IL-8 functions
neutrophil chemotaxis - be late for your taxi
IL-10 main sources
Th2 cells
IL-10 functions
Inhibits Th1 cytokine production
Also known as human cytokine synthesis inhibitory factor and is an ‘anti-inflammatory’ cytokine
IL-12 main sources
Dendritic cells, macrophages, B cells
IL-12 functions
Activates NK cells and stimulates differentiation of naive T cells into Th1 cells
Tumour necrosis factor-α main sources
Macrophages
Tumour necrosis factor-α functions
Induces fever
Neutrophil chemotaxis
Interferon-γ main sources
Th1 cells
Interferon-γ main function
Activates macrophages
