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Host and Defense > Immune system > Flashcards

Immune system Flashcards

1
Q

Mechanical protection agains bacteria

A

Flow of fluid, hardness of skin, perspiration, mucus,

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2
Q

Chemical protection

A

a

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3
Q

Microbiological

A

Normal flora

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4
Q

Defensins

A

Small cysteine rich cataionic proteins and function as host defense peptides

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5
Q

alpha defensins

A

leukocytes, Paneth cells

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6
Q

beta defensins

A

leukocytes, epithelial cells

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7
Q

PAMPs

A

Pathogen Associated Molecular Patterns

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8
Q

Nonclonal

A

Innate immunity, identical receptors on all cells of the same lineage.

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9
Q

Primary granules

A

MPO

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10
Q

Secondary granules

A

Lactoferrin

Most numerous.

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11
Q

Tertiary granules

A

gelatinase and metalloproteinases.

Used to enter tissues

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12
Q

NETS

A

very sticky with antimicrobial properties, nuclear material, DNA with histones

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13
Q

LAD

A

leukocyte adhesion deficiency

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14
Q

Interferons

A

cytokines expressed in response to viral infections

Induce to viral replication.

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15
Q

Type I interferons

A

Jack stat mechanism

antiviral state and enhances the killing activity of NK cells

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16
Q

Type II interferons

A

produced by NK cells, activate macrophages

17
Q

Major mediators of inflamation

A

IL-1, IL-6 and TNF alpha

18
Q

C3 convertace

A

CebBb

19
Q

properdin

A

Accelerator and also a limiting factor. positive regulator of alternative pathway

20
Q

Factor H and I

A

Inhibitors of C3b to iC3b.

21
Q

C5 convertace

A

C3b2Bb, has affinity for C5

22
Q

C8 deficiency

A

recurrnt infections due to lack of membrane lysis of bacteria. specially Neisseria.

23
Q

IgM

A

pentomeric= 5 stuck together

24
Q

Regulation of complement

A

C1 INh, DAF ( decay accelerating factor), CD59

25
Q

DAF

A

Decay accelerating factor, regulates early, preens Bb from binding to C3b.

26
Q

Problems with CD59

A

Paroxysmal nocturnal hemoglobinuria

Host and Defense (6 decks)

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