Immune System Flashcards

1
Q

Define the terms innate and adaptive immunity

A

Innate immunity is the body’s first line of defense against pathogens, providing immediate but non-specific responses. Adaptive immunity involves T and B lymphocytes that provide a specific and long-lasting response to pathogens.

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2
Q

What is the role of innate defences in preventing and limiting infection?

A

Innate defences provide immediate protection through physical barriers, inflammatory responses, and the action of white blood cells.

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3
Q

What is the action of lymphocytes in mediating adaptive immunity?

A

Lymphocytes, specifically T and B cells, respond to specific antigens, leading to the production of antibodies and the activation of cell-mediated responses.

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4
Q

List the types of infectious organisms mentioned

A
  • Worms
  • Protozoa (protist)
  • Viruses
  • Bacteria
  • Fungi
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5
Q

True or False: Antibiotics are effective against viral infections.

A

False

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6
Q

What chromosome is mainly responsible for converting the female body template to a male one?

A

The Y chromosome

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7
Q

What is the function of tears in the immune response?

A

Tears wash away dirt and contain an antiseptic substance.

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8
Q

What is phagocytosis?

A

Phagocytosis is the process by which phagocytes engulf and digest pathogens.

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9
Q

What are natural killer cells responsible for?

A

Natural killer cells are responsible for immunological surveillance and direct attack on a range of microbes, infected, and cancerous cells.

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10
Q

What role do mast cells play in the immune response?

A

Mast cells are involved in inflammation and release chemicals that contribute to the inflammatory response.

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11
Q

What is the inflammatory response characterized by?

A

Local tissue swelling, erythema, heat, and pain.

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12
Q

What triggers the emigration of phagocytes during inflammation?

A

Cytokines secreted by neutrophils attract monocytes through chemotaxis.

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13
Q

Fill in the blank: _______ increase the temperature set-point during fever.

A

[Pyrogens]

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14
Q

What is the function of the lymphatic system in the innate immune system?

A

The lymphatic system filters lymph through lymph nodes to recognize and raise defense against pathogens.

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15
Q

What is the glymphatic system in the brain?

A

A macroscopic waste clearance system that uses perivascular channels for elimination of soluble proteins and metabolites.

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16
Q

What are the components of the adaptive immune system?

A
  • T lymphocytes
  • B lymphocytes
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17
Q

What type of immune response do memory T cells participate in?

A

Cell-mediated response

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18
Q

What do plasma cells secrete?

A

Antibodies or immunoglobulins

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19
Q

List the types of immunoglobulins produced by plasma cells

A
  • IgG
  • IgE
  • IgD
  • IgM
  • IgA
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20
Q

What is the difference between primary and secondary immune response?

A

Primary immune response is slower and less effective, while secondary immune response is faster and more powerful due to memory cells.

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21
Q

Fill in the blank: _______ immunity can be acquired naturally or artificially.

A

[Active immunity]

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22
Q

What is passive immunity?

A

Immunity acquired through the transfer of antibodies, either naturally or through clinical therapy.

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23
Q

What can high levels of C-reactive protein indicate?

A

Inflammation, and possibly infection in the context of clinical signs.

24
Q

True or False: Inflammation is only caused by infectious agents.

25
How do sympathetic nervous system stimuli affect the immune system?
They result in the release of noradrenaline, increasing the production and release of monocytes into circulation.
26
What is the gold-standard evidence for infection by a microorganism?
A positive blood or cerebrospinal fluid culture.
27
What is the immune system sometimes referred to as?
A 'floating brain' due to its complexity.
28
What is a marker of inflammation that may imply infection?
Elevated protein concentration ## Footnote High levels may indicate infection in the context of supportive clinical signs.
29
What is considered gold-standard evidence for infection by a microorganism?
Positive blood or cerebrospinal fluid culture
30
What is the role of inflammation in the absence of infection?
Inflammation is important even without infection
31
How do some experts view the immune system?
As a ‘floating brain’ due to its cleverness and complexity
32
What are the learning outcomes of the lecture?
* Define innate and adaptive immunity * Discuss role of innate defences * Understand lymphocyte action in adaptive immunity * Apply immune mechanisms to immunological resistance * Draw links between immunity and other fields
33
What is the structure that surrounds the genetic material of a virus?
Capsid
34
What are subunits that make up the protein shell of a virus called?
Capsomers
35
What is the function of surface proteins on viruses?
Attach to specific receptors on host cells
36
What type of genetic material can be found in viruses?
RNA or DNA
37
What are the steps in how viruses reproduce inside host cells?
* Attach to host cell receptors * Enter the cell * Shed protein shell * Reproduce genetic material * Form new protein shells * Exit the cell
38
What structure in bacteria controls the entrance and exit of substances?
Plasma membrane
39
What is the role of the bacterial cell wall?
Provides rigidity and structure
40
What is a plasmid?
A circle of DNA containing extra beneficial genes
41
What is the function of ribosomes in bacteria?
Manufacture proteins
42
What is the role of toxins produced by bacteria?
Disrupt normal chemical reactions in body cells
43
What happens to body cells when toxins are released by bacteria?
Cells are unable to function and die
44
What is the function of neutrophils in the blood?
Act as white blood cells involved in immune response
45
What do phagocytes do during the inflammatory response?
Engulf and destroy foreign organisms
46
What triggers the inflammatory response?
Foreign organisms invading through broken skin
47
What is haemopoiesis?
The process of blood cell production from pluripotent stem cells
48
What are the two major types of immune responses?
* Innate immunity * Adaptive immunity
49
What are the three types of T cells in the adaptive immune system?
* Cytotoxic T cell * Helper T cell * Suppressor T cell
50
What do Cytotoxic T cells use to attack pathogens?
* Perforin * Granzymes * Lymphotoxin * Stimulating apoptosis
51
What is the function of Memory T cells?
Enable quicker secondary response to the same antigen
52
What happens during the allergic reaction in response to an allergen?
Antibodies bind to mast cells, causing histamine release
53
What is the role of histamine in allergic reactions?
Causes symptoms of allergy
54
What is the primary fluid component of blood?
Plasma
55
What are the main components of blood?
* Plasma * Red blood cells * White blood cells * Platelets
56
What is the function of the lymphatic system?
Transport lymph and facilitate immune responses
57
What are lymph nodes primarily involved in?
Immune responses and filtration of lymph