Immune System Flashcards
Anti-histamines
Immune System
Chlorphenamine, Cetirizine
MoA:
H1 histamine receptor blockade
Indication:
Hay fever, urticaria
Adverse Effects/Interactions:
H1 histamine receptor blockade
Glucocorticoids
Immune System
Prednisolone, hydrocortisone,
Dexamethasone
MoA:
Intracellular transcription factor interactions, gene expression
Indication:
Suppression of inflammatory diseases (e.g. Crohn’s, RA)
Adverse Effects/Interactions:
Weight gain, muscle atrophy, oral antidiabetics
Calcineurin inhibitor
Immune System
Cyclosporin, Tacrolimus
MoA:
Inhibition of T cell signalling
Indication:
Solid organ transplantation,
Eczema (topical)
Adverse Effects/Interactions:
Hypertension
aspirin
Classical alkylating agents
Anti-neoplastic drugs
Cyclophosphamide
MoA:
DNA crosslinking
Indication:
Broad spectrum of malignancies
Adverse Effects/Interactions:
Hair loss, bone marrow suppression, nausea
Taxanes
Anti-neoplastic drugs
Paclitaxel, Docetaxel
MoA:
Disruption of microtubule function in mitotic spindles
Indication:
Broad spectrum of malignancies
Adverse Effects/Interactions:
Hair loss, bone marrow suppression, nausea
Antifolates
Anti-neoplastic drugs
Methotrexate
MoA:
Inhibition of dihydrofolate reductase and DNA synthesis
Indication:
Broad spectrum of malignancies
Adverse Effects/Interactions:
Antipyrimidines
Anti-neoplastic drugs
Fluorouracil, Cytarabine
MoA:
Inhibition of RNA and DNA synthesis
Indication:
Broad spectrum of malignancies
Adverse Effects/Interactions:
Hair loss, bone marrow suppression, nausea
Antipurines
Anti-neoplastic drugs
Mercaptopurine, Thioguanine
MoA:
Inhibition of RNA and DNA synthesis
Indication:
Broad spectrum of malignancies
Adverse Effects/Interactions:
Hair loss, bone marrow suppression, nausea
Antineoplastic monoclonal antibodies (examples)
Anti-neoplastic drugs
Trastuzumab
Rituximab
Nivolumab
MoA:
Targeting of cells overexpressing Human Epidermal Growth Factor Receptor-2 (HER2) for tumour reduction & destruction
Targeted destruction of CD20+ B cells
Stimulation of anti-tumour responses via blocking PD-1
Indication:
Early breast cancer
Follicular lymphoma, Non-Hodgkin’s lymphoma
Melanoma
Adverse Effects/Interactions:
Fever, chills
Immunomodulator
Anti-neoplastic drugs
Lenolidamide
MoA:
Stimulation of T cell responses
Indication:
Myeloma
Adverse Effects/Interactions:
Foetal risk
Selective estrogen receptor modulator (SERM)
Anti-neoplastic drugs
Tamoxifen
MoA:
Inhibition of oestrogen receptor function and cell proliferation in breast
Indication:
Breast cancer
Adverse Effects/Interactions:
Luteinising hormone releasing hormone (LHRH) receptor agonist
(Anti-neoplastic drugs)
Goserelin
MoA:
Synthetic analogue of LHRH. Activates LHRH receptor function leading to sustained reduction in testosterone
Indication:
Prostate cancer
Adverse Effects/Interactions:
