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Phase II Drugs List > Gastrointestinal System > Flashcards

Gastrointestinal System Flashcards

1
Q

Antacids

Drugs for treating disorders of gastric and pancreatic secretion

A

Aluminium & magnesium hydroxide/calcium carbonate

MoA:
Gastric acid neutralisation

Indication:
Dyspepsia, heartburn

Adverse effects/interactions:
Nausea

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2
Q

Antacid + Alginates

Drugs for treating disorders of gastric and pancreatic secretion

A

Sodium alginate with sodium bicarbonate

MoA:
Gastric acid neutralisation

Indication:
Gastric reflux

Adverse effects/interactions:
Abdominal distension

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3
Q

H2-receptor antagonists

Drugs for treating disorders of gastric and pancreatic secretion

A

Famotidine, Cimetidine

MoA:
Blockade of gastric H2 histamine receptors

Indication:
Stomach ulcers

Adverse effects/interactions:
Dizziness

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4
Q

Proton-pump inhibitors

Drugs for treating disorders of gastric and pancreatic secretion

A

Omeprazole, Lansoprazole

MoA:
Blockade of stomach acid transporters

Indication:
Stomach & duodenal ulcers, gastric reflux

Adverse effects/interactions:
Headache, diarrhoea
Warfarin

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5
Q

Pancreatic Enzymes

Drugs for treating disorders of gastric and pancreatic secretion

A

Pancreatin

MoA:
Restoration of pancreatic enzymes

Indication:
Pancreatic insufficiency - Cystic fibrosis, pancreatitis

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6
Q

Bulk Laxatives

Laxatives and Diarrhoea Treatments

A

Methylcellulose, Isphagula Husk

MoA:
Water absorption in intestinal lumen to bulk stools

Indication:
Constipation

Adverse effects/interactions:
Rare

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7
Q

Faecal Softener

Laxatives and Diarrhoea Treatments

A

Docusate, Arachis Oil

MoA:
Stimulates water & electrolyte secretion into intestinal lumen

Indication:
Constipation

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8
Q

Osmotic Laxatives

Laxatives and Diarrhoea Treatments

A

Macrogol (PEG), Lactulose,
Magnesium Sulphate, Magnesium Hydroxide

MoA:
Water retention in intestinal lumen

Indication:
Constipation

Adverse effects/interactions:
Stomach cramps
Antiepileptics

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9
Q

Stimulant Laxatives

Laxatives and Diarrhoea Treatments

A

Bisacodyl, Senna

MoA:
Increase intestinal motility

Indication:
Constipation

Adverse effects/interactions:
Nausea

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10
Q

Opioid anti-motility agents

Laxatives and Diarrhoea Treatments

A

Loperamide, codeine

MoA:
Agonist for µ-opioid receptors in myenteric plexus. Blocks intestinal muscarinic receptors

Indication:
Diarrhoea

Adverse effects/interactions:
Rare

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Phase II Drugs List (10 decks)

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