Immune reactions/responses

Question 1

The state when an immune cell matures but does not respond to antigens is called _______.

Answer 1

anergy

Question 2

What molecule causes transplant rejection reactions?

Answer 2

foreign MHC on the transplant

Question 3

Which class MHC protein has two polypeptides and an alpha and beta chain?

Answer 3

MHC II

Question 4

Which cells have MHCI on their surface?

Answer 4

all cells except RBCs

Question 5

Which class MHC proteins is the main determinant of organ rejection?

Answer 5

MHC II

Question 6

What is the role of MHC II?

Answer 6

presents non-self antigens

Question 7

What are two mechanisms of antigenic shift?

Answer 7

DNA re-arrangement, and RNA segment re-arrangement

Question 8

Is transplant rejection reversible?

Answer 8

yes, with immunosupressive drugs (e.g. cyclosporin).

Question 9

Which cells have MHC II? (3)

Answer 9

macrophages, monocytes, dendritic cells (“professional antigen presenting cells”)

Question 10

All nucleated cells have which type of MHC protein?

Answer 10

MHC 1

Question 11

What are the three MHC II genes?

Answer 11

DP, DQ, DR

Question 12

What is antigenic variation?

Answer 12

when pathogens changes their proteins (surface, flagellar, etc) so that they can escape the immune systems antibodies)