immune popcorn Flashcards
allergic and helminth responses
basophils
release histamine and heparin
basophils and mast cells
reduction of clotting
heparin basophils
least common PNM
basophils
circulating in bloodstream and present in organs particularly GI and Respiratory tract
eosinophils
release H2o2 and oxygen radicals
eosinophils
viruses and parasites
eosinophils
release leukotrienes (lipid signaling)
eosinophils
active in allergic reactions and asthma
eosinophils
stimulate Tlymphocytes and are weakly phagocytic
eosinophils
most abundant granulocyte
Neutrophils
circulating the blood stream
Neutrophils
basophils
active against fungi and bacteria
Neutrophils
first responders
Neutrophils
release other cytokines to recruit monocytes & macrophages
Neutrophils
Strongly Phagocytic
Neutrophils
Neutrophil Extracellular Traps (NETs)
Neutrophil
fever
IL 1 and 6
acute phase response
IL-6
activates activates neutropjils
TNF
block virus replication
interferons
mature in tissues
mast cells
agranular
monocytes
rise to dendritic cells & macrophages
stored in spleen
monocytes
strongest APC
dendritic cells
langerhans cells
dendritic cells
hiv
release TNF and ILs
macrophages
Specialized macrophages within the liver
Destroy bacteria & old RBCs
kupffer cells
Chronic activation of Kupffer cells (toxins, EtOH
liver damage
against viruses and cancerous cells
NKC
perforins and proteases
NKC
bloodstream, liver and spleen
NKC
made in liver
complement proteins
c3
most abundant complement protein in humans
Opsonization
enhancing phagocytosis of antigens by ‘marking’ them for destruction
