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Immuno - Callan > Immune Modulating Therapies 2 > Flashcards

Immune Modulating Therapies 2 Flashcards

1
Q

Side Effects: Cyclophosphamide

A. Osteoporosis
B. Infertility, cystitis, malignancy
C. Progressive multifocal leukoencephalopathy
D. Neutropenia risk high if TPMT low
E. Nephrotoxicity
A

B. Infertility, cystitis, malignancy

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2
Q

Side Effects: Prednisolone

A. Osteoporosis
B. Infertility, cystitis, malignancy
C. Progressive multifocal leukoencephalopathy
D. Neutropenia risk high if TPMT low
E. Nephrotoxicity
A

A. Osteoporosis

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3
Q

Side Effects: Azathioprine

A. Osteoporosis
B. Infertility, cystitis, malignancy
C. Progressive multifocal leukoencephalopathy
D. Neutropenia risk high if TPMT low
E. Nephrotoxicity
A

D. Neutropenia risk high if TPMT low

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4
Q

Side Effects: Tacrolimus

A. Osteoporosis
B. Infertility, cystitis, malignancy
C. Progressive multifocal leukoencephalopathy
D. Neutropenia risk high if TPMT low
E. Nephrotoxicity
A

E. Nephrotoxicity

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5
Q

Side Effects: Mycophenolate mofetil

A. Osteoporosis
B. Infertility, cystitis, malignancy
C. Progressive multifocal leukoencephalopathy
D. Neutropenia risk high if TPMT low
E. Nephrotoxicity
A

C. Progressive multifocal leukoencephalopathy

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6
Q

Agents directed at cell surface molecules: Basiliximab (Anti-IL2 receptor)

A. Inhibits leukocyte migration but may only be used in highly active remitting/relapsing MS
B. Binds to CD80 and CD86 on antigen-presenting cells and inhibits T cell activation and is effective in rheumatoid arthritis
C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis
D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis
E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

A

E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

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7
Q

Agents directed at cell surface molecules: Abatacept (CTLA4-Ig fusion protein)

A. Inhibits leukocyte migration but may only be used in highly active remitting/relapsing MS
B. Binds to CD80 and CD86 on antigen-presenting cells and inhibits T cell activation and is effective in rheumatoid arthritis
C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis
D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis
E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

A

B. Binds to CD80 and CD86 on antigen-presenting cells and inhibits T cell activation and is effective in rheumatoid arthritis

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8
Q

Agents directed at cell surface molecules: Rituximab (Anti-CD20)

A. Inhibits leukocyte migration but may only be used in highly active remitting/relapsing MS
B. Binds to CD80 and CD86 on antigen-presenting cells and inhibits T cell activation and is effective in rheumatoid arthritis
C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis
D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis
E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

A

C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis

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9
Q

Agents directed at cell surface molecules: Natalizumab (Anti-α4 integrin)

A. Inhibits leukocyte migration but may only be used in highly active remitting/relapsing MS
B. Binds to CD80 and CD86 on antigen-presenting cells and inhibits T cell activation and is effective in rheumatoid arthritis
C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis
D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis
E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

A

A. Inhibits leukocyte migration but may only be used in highly active remitting/relapsing MS

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10
Q

Agents directed at cell surface molecules: Tocilizumab (Anti-IL6 receptor)

A. Inhibits leukocyte migration but may only be used in highly active remitting/relapsing MS
B. Binds to CD80 and CD86 on antigen-presenting cells and inhibits T cell activation and is effective in rheumatoid arthritis
C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis
D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis
E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

A

D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis

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11
Q

Immunosuppression: Psoriasis

A. Treatment options include inhibition of RANK ligand
B. Treatment options include inhibition of IL12/23, TNF alpha and IL17A
C. Treatment options include inhibition of IL6, TNF alpha and depletion of B cells

A

B. Treatment options include inhibition of IL12/23, TNF alpha and IL17A

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12
Q

Immunosuppression: Rheumatoid arthritis

A. Treatment options include inhibition of RANK ligand
B. Treatment options include inhibition of IL12/23, TNF alpha and IL17A
C. Treatment options include inhibition of IL6, TNF alpha and depletion of B cells

A

C. Treatment options include inhibition of IL6, TNF alpha and depletion of B cells

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13
Q

Immunosuppression: Osteoporosis

A. Treatment options include inhibition of RANK ligand
B. Treatment options include inhibition of IL12/23, TNF alpha and IL17A
C. Treatment options include inhibition of IL6, TNF alpha and depletion of B cells

A

A. Treatment options include inhibition of RANK ligand

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Immuno - Callan (7 decks)

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