Immune Flashcards
When in the course of a transplant will a patient be susceptible to opportunistic infections?
After 1 month of starting immunosuppressive medications`
When is GVH most common?
!st 100 days of transplant
How often do stem cell transplant patients have GVHD?
50%
What are the symptoms in the first week of GHVD?
Rash, fever, leading to hepatitis, fluid retention, shock
What is the treatment for chronic GVHD?
Steroids
What must be done to the pRBCs prior to transfusion for a patient with any type of transplant?
Irradiated
What are the s/sx of a kidney transplant rejection?
HTN, decreased uop, increased creatinine
What are the primary s/sx of a lung transplant rejection?
SOB
CXR with infiltrates
Why does atropine not work for cardiac transplant patients?
Vagus nerve is not replaced during transplant
What are the reversal agents for angioedema?
Icatibant
Ecallantide
What is DRESS syndrome? s/sx?
Drug related eosinophilia with systemic symptoms
Fever, rash, eosinophilia, transaminitis, atypical lymphocytes
What is the mortality rate with DRESS?
10%–they’re sick
What is the treatment for raynaud’s?
CCB
What are the components of CREST syndrome?
Calcinosis Raynaud's Esophageal dysmotility Sclerodactyly Telangiectasias
What are the manifestations of scleroderma crisis (heart, lungs, kidneys)
- Renal crisis/HTN
- pHTN, alveolar hemorrhage
- CHF, arrhythmias
What is the emergent complication from dermatomyositis?
Rhabdo
What is the treatment for dermatomyositis (from the ER)?
Steroids
Gower’s sign = ?
Polymyositis
What are the s/sx of polymyositis?
Proximal muscle weakness, Gower’s sign
What is the treatment for polymyositis?
Steroids, immunosuppressants
What is Behcet’s syndrome, and what are the s/sx?
Systemic vasculitis that classically causes painful oral/genital ulcers, uveitis, erythema nodosum
What is the inheritance pattern of Marfan’s syndrome?
AD
What infection is associated with polyarteritis nodosa?
Hep B
What organ system is typically spared with polyarteritis nodosa?
Lungs
beads on a string appearance of the renal arteries = ?
Polyarteritis nodosa
What vessel is classically affected with Takayasu arteritis?
Aorta and its branches
ESR over what level is characteristic of giant cell arteritis?
50
What is the eponym for thromboangiitis obliterans?
Burger’s disease
What skin finding is commonly associated with sarcoidosis?
Erythema nodosum
What enzyme level is elevated with sarcoidosis?
ACE
What EKG finding may be present on a patient with rheumatic fever?
Prolonged PR
Which step associated problem is preventable with PCN treatment: rheumatic fever or glomerulonephritis
Rheumatic fever is preventable, glomerulonephritis is not
