Imm Mech Against Parasite Infestation

Question 1

Antigenic bariation

Answer 1

Trypansome can switch expr to a different variant surface glycopro so Ab can’t recognise anymore

Question 2

Imm changes in gut to encourage worm expulsion

Answer 2

Incr perm of gut epi so plasma pros IgA and mast cell proteases leak out
Gut epi cells prolif
Increased gonlet cell
No so incr mucus quantity
Incr gut motility