IMHA Flashcards
1
Q
What is primary hemostasis
A
Platelets (number and function) and formation of a platelet plug
2
Q
What is secondary hemostasis?
A
Formation of a fibrin mesh that stabilizes the platelet plug
3
Q
What sets off primary hemostasis?
A
Damage to the endothelium of a blood vessel
- vWF and GP1 released from collagen causing platelets to adhere
- Platelets stimulated to release ADP, TxA1, vWF
4
Q
T/F: Platelet activation recruits more platelets
A
True
5
Q
What defects in primary hemostasis can occur?
A
- Decreased platelets/thrombocytopenia
- Poorly functional platelets
- Lack of vWF (platelet and collagen derived)
6
Q
What defects in secondary hemostasis can occur?
A
Lack of or defects in any of the cogulation factors
7
Q
What are the clinical signs of primary hemostatic defects?
A
- Petechia
- Ecchymosis
- Oozing from mucosal sites
8
Q
What are the clinical signs of secondary hemostatic defects?
A
- Bleeding into a body cavity
- Large SQ hematomas
9
Q
T/F: Severe primary and secondary coagulopathies often have the same or similar clinical presentations.
A
True
