Images2 Flashcards
Spinothalamic tract
(a) Synapses
(b) Decussations
Spinothalamic tract for pain/temp
(a) Synapses twices
- in dorsal horn
- at VPL of the thalamus
(b) Decussates across the anterior gray commisure 1-2 levels above where it enters the SC
Where in the brainstem do each of the cranial nerves sit?
CN I and II don’t go thru the brainstem
CN III, IV = midbrain
-midbrain stroke can cause 3rd nerve palsy
CN V, VI, VII, VIII = pons
=> brainstem glioma around the pons can present w/ 6th nerve palsy
CN XI, X, XI, XII = medulla
Describe the vascular territories of the following cross section
- note little sliver of ACA on top, then large chunk MCA b/c we’re deep here
- then inferiorly PCA
Pt w/ visual field deficit in the RUQ, locate the lesion (be specific)
Lesion = Optic radiations/Meyer’s loops = axonal connections btwn the lateral geniculate nucleus of the thalamus and the primary visual cortex of the occipital lobe
RUQ visual field deficit = optic radiations in the temporal lobe on the left
- superior quadrant affected 2/2 lesion of Meyer’s loops (temporal lobe)
- inferior quadrant 2/2 lesion to superior optic radiation (parietal lobe)
Locate the lesion
Left eye: mild ptosis w/ constricted pupil, also probably left sided anhidrosis = Horner’s syndrome 2/2 loss of sympathetic innervation to left side
Lesion of the superior cervical ganglion (houses the sympathetics)
-also can be 2/2 carotid artery dissection (or vertebral artery dissection = Wallenberg syndrome)
Expected MRA finding in a pt w/ 3rd nerve palsy
B/c of where the CN III exits the brainstem, right under the PCOMM => CNIII gets compressed by PCOMM aneurysm
Pt w/ the following MRI is likely to present w/ what visual complaint?
Pituitary pathology, possible etiologies adenoma, craniopharyngioma, etc
No matter what the etiology: getting compression of the optic nerve, causing bitemporal hemianopsia (loss of lateral fields of view)
Corticospinal tract
(a) Synapses
(b) Decussates
(b) Decussates at the medullary pryamids
(a) Synapses in the anteiror horn of the spinal gray matter before learing
Cuneate vs. gravile fasciculus
Both are dorsal column fibers
- cuneate fasciculus carries fibers from the arms (lateral): lateral b/c added on as the tract ascends
- gracile fasciculus carries fibers from the legs (medial)
Occlusion of the anterior spinal artery
Effect on each of the three spinal cord pathways
- weakness bilaterally (b/c hitting both lateral corticospinal tracts)
- loss of pain and temp bilaterally (b/c hitting both spinothalamic tracts)
- preservation of proprioception and vibration b/l (b/c dorsal columns not invovled
When pt looks to the right he cannot adduct his left eye, and there is abducting nysagmus of the right eye
-convergence preserved
Locate the lesion
Lesion of the medial longitudinal fasciculus (MLF) which connects CNIII and CNVI to allow for conjugate gaze
Conjugate gaze = simultaneous activation of medial and lateral rectus muscles to allow eyes to look in one direct simultaneously
Cavernous sinus
(a) Name 2 things in it besides cranial nerves
(b) What sits on top?
(b) Underneath?
Cavernous sinus
(a) Internal carotid artery and the pitutiary galnd
(b) Right on top sits the optic chiams
(c) Sinuses are right underneath
Differentiate the side effect by peripheral vs. central seventh nerve palsy
Central 7th = lesion of the motor pathway above the facial nucleus (supranuclear lesion)
- spares upper facial muscles, so you can move your forehead
- causes weakness of lower part of the phase CONTRALATERAL to the lesion
Peripheral 7th = lesion of the facial nucleus in the pons or the facial nerve itself
-weakness of the entire face IPSILATERAL to the lesion
Dorsal Column/Medial Lemniscus pathway
(a) Synapses
(b) Decussates
Dorsal columns for proprioception and fine touch
(a) Synapses twices
- in lower medulla just before decussating
- in VPL of thalamus
(b) Decussates in lower medulla forming the medial lemniscus throughout the brainstem
Initial sign of posterior communicating artery anurysm
Ipsilateral dilated pupil
-Compressive lesion (parasym fibers are on the outside) so parasymp fibers are lost before the EOM are affected
Pt p/w bitemporal hemianopsia and CT showing pitutiary mass w/ calcifications
(a) Dx
(b) Mechanism of visual complaints
(a) Dx = craniopharyngioma
- calcified on CT
(b) Compression on optic nerve
Describe Brown-Sequard syndrome
- weakness ipsilateral to the lesion
- loss of proprioception/vibration on same side of the lesion
- loss of pain/temp opposite the lesion
Describe finding’s of Bell’s palsy
Unilateral facial paralysis
- can’t close eye on affected side
- can’t smile (mouth drooped)
- smoothing of forehead (can’t raise eyebrown muscles)
- loss of nasolabial fold
Also may find: dry eyes, facial twitching, dry mouth, impaired taste
What is the thalamic nuclei responsible for vision?
Lateral geniculate nucleus of the thalamus
= relay center for the visual pathway
-connects optic nerve to the occipital lobe by sending axons thru the optic radiations
What is the tract of Lissauer?
Gray matter tract of entering spinothalamic fibers
-right where the spinothalamic fibers enter
Pineal gland
(a) Function
(b) appearance on CT
(c) Most common pineal-region tumor
Pineal gland
(a) Secretes melatonin to regulate sleep/wake cycle
- stimulated by darkness, inhibited by light
(b) Physiologically calcified on CT
(c) Germinomas = most common pineal-region tumors
Pinealomas = primary pineal tumors, often clinically silent until large enough to compress vertical gaze center of the midbrain (=> vertical gaze palsy)
Diagnostic test for BPPV
Dix-Hallpike maneuver: basically move the pt (w/ head tilted at 45 degrees) from seated to supine and see if the nystagmus is in the same direction as gravity
Label the main parts of this midbrain cross section
- see CN III leaving out the center
- red nucleus b/l
- substantia nigra (Parkinsonism…)
- cerebral peduncle superiorly
Describe the manifestations of central cord syndrome due to a syrinx in the cervical spine
Loss of pain/temp in ‘shawl distribution’ (aka b/l) b/c hitting the spinothalmic tract as it’s decussating
-can get weakness if the anterior horns are affected
(a) After stroke affecting the left frontal lobe, which way will eyes deviate?
(b) Seizure focus originating in left frontal lobe, which way will eyes deviate?
(a) Eyes deviate left
- towards the lesion b/c right eye fields are acting unopposed (to deviate eyes left)
(b) Eyes deviate right, eyes deviate away from seizure focus
Frontal eye fields deviate eyes in the opposite direction
Describe the path CN III takes to emerge from the brainstem
CN III runs under the PCOMM then right between the PCA (posterior cerebral) and superior cerebellar artery to exit the brainstem
45 yo M can’t move left eye
- left fixed, dilated pupil w/ ptosis
- numb on upper and middle face
Locate the lesion
Lesion of the cavernous sinus: only place where CN III, IV, VI, V1, V2 all can be hit at once
CN III, IV, VI loss = loss of EOM, dilated pupil (loss of parasymps from CN III), ptosis b/c CN III innervates levator palpebrae superioris
-facial numbness from V1/V2
Pt p/w upgaze paralysis 2/2 compression of the vertical gaze center in the midbrain (circled in red)
What type of tumor?
Tumor of the pineal gland (pinealoma)
-often silent until compresses midbrain enough to cause vertical upgaze restriction
Maneuvers for tx of BPPV
Epley maneuvers
-series of positional changes to help reposition otolithic material in the posterior semicircular canal
Differentiate Rinne and Weber test
Weber test: tuning fork on forehead, sound should be the same in both ears
- conductive hearing loss: sounds louder in affected ear
- sensorineural hearing loss: sound louder in unaffected ear
Rinne test: Press tuning fork against the mastoid, then hold just next to the ear
- louder next to ear than on bone = normal (air conduction better than bone conduction)
- louder on bone than next to ear = conductive hearing loss
Locate the lesion that causes
(a) Monocular blindness
(b) Homonymous hemianopsia
(c) Homonymous hemianopsia w/ macular sparing
(d) Bitemporal hemianopsia
(e) Upper quadrantanopia
Describe the venous drainage system of the brain
- Inferior sagittal and great cerebral vein (of Galen) drain into straight sinus
- Superior sagittal sinus meets straight sinus forming the confluence of sinuses that continues downwards as the transverse sinus
- cavernous sinus (whcih the opthalmic veins drain into) drains into the transverse sinus forming the sigmoid sinus
- sigmoid sinus then continues down into internal jugular vein
