ILAs Flashcards
Management of juvenile infant arthritis?
-NSAIDs, such as ibuprofen
-Steroids, either oral, intramuscular or intra-artricular in oligoarthritis
-DMARDs- methotrexate, sulfasalazine and leflunomide
-Biologics -TNF inhibitors etanercept, infliximab and adalimumab
What is still disease
-a subtype of Juvenile idiopathic arthritis
-which is systemic and can affect joints and organs
Signs of stills disease (systemic arthritis) (8)
-Subtle salmon-pink rash
-High swinging fevers
-Enlarged lymph nodes
-Weight loss
-Joint inflammation and pain
-Splenomegaly
-Muscle pain
-Pleuritis and pericarditis
Complication of Systemic JIA?
-macrophage activation syndrome
What is macrophage activation syndrome?
-severe activation of the immune system and inflammatory response
Investigation that will suggest Macrophage activation syndrome?
Low ESR
Key NON INFECTIVE differentials of a high grade fever for 5+ days? (4)
-Kawasaki disease
-stills’s disease
-rheumatic fever
-leukemia
5 Subtypes of JIA?
-Systemic JIA
-Polyarticular JIA
-Oligoarticular JIA
-Enthesitis related arthritis
-Juvenile psoriatic arthritis
Macrophage activation syndrome presentation
-stills disease presentation
PLUS
-aneamia
-DIC
-thrombocytopenia
-non blanching rash
What is polyarticular arthritis?
-Idiopathic inflammatory arthritis in 5 joints or more
-tends tot be symmetrical
What is oligoarticular JIA?
- idiopathic inflammatory arthritis, involving 4 joints or less
-tends to affect larger joints like hips and knees
What presentation is commonly associated with Oligoarticular JIA?
Anterior uveitis
Which group are the sites related arthritis more common in
Males over 6 years
- equivalent to seronegative spondyloarthropathies such as Ankylosing spondylitis, psoriatic arthritis and reactive arthritis
What is an enthesis?
Point at which the tendon of a muscle inserts into a bone
What is Enthesitis-Related Arthritis?
Inflammation of the insertion point of a tendon to bone
