IHD Flashcards
MCC of myocardial ischemia
Atherosclerotic disease of an EPICARDIAL CORONARY ARTERY
Major determinants of coronary resistance
Prearteriolar vessels (R2) Arteriolar and intramyocardial capillary vessels (R3)
Predilection for atherosclerotic plaques
Develop at sites of increased turbulence in coronary flow
Usually reflects NON-transmural, intramyocardial ischemia in ECG
Transient T wave inversion
May be a patchy SUBENDOCARDIAL ischemia in ECG
Transient ST-segment depression
More severe TRANSMURAL ischemia in ECG
ST segment elevation
May cause angina in the absence of coronary atherosclerosis
Aortic stenosis
Aortic regurgitation
Pulmonary hypertension
Hypertrophic cardiomyopathy
Major benefit of high-sensitivity CRP in IHD
Reclassify the risk in the “intermediate” risk category on the basis of traditional risk factos
Significant indication of increased risk of adverse outcomes from IHD
LVH
The presence is a significant indication of increased risk of adverse outcomes from IHD
LVH
Positive result of exercise ECG stress test indicates
Likelihood of CAD is 98% in males who are >50 years old with a history of typical angina and who develop chest discomfort during the test
Normal response to a graded exercise stress test
Progressive increases in heart rate and BP
More sensitive than exercise electrocardiography in the diagnosis of IHD
Stress echo
On cardiac cath, the most important signs of Lv dysfunction and associated with poor prognosis
Elevations of LV end diastolic pressure and ventricular volume
Reduced EF
Major mechanisms of action of nitrates
Systemic venodilation with concomitant reduction in LVEDV and pressure
