ID3

Question 0

ILs of schistosomiasis

Answer 0

Il4, IL5, IL13
IL4 and IL13 activate macrophage–>stimulates pathway that stimulates production of collagen precursors and favors fibrosis

Question 1

schistosomiasis

Answer 1

tropical freshwater bloodflukes
-penetrates skin, develops in mesenteric veins, adopt host antigens, deposit eggs–>eggs elicit eospinophilic infiltrate, granulomas, dense fibrosis

Question 2

what does schistosomiasis lead to

Answer 2

fibrosis (scarring) of liver–>portal hypertension, ascites

hematuria, sometimes squamous cell carcinoma of bladder

Question 3

immunity with schistosomiasis

Answer 3

acute TH1 response with INg and TNF (febrile symptoms)

as chronic disease happens–>TH2 with eosinophils & fibrosis

Question 4

what does shisto NOT cause

Answer 4

destroyed hepatocytes, so biosynthetic function of liver is maintained– clotting factors, albumin levels same

Question 5

influenza is a

Answer 5

RNA virus

Question 6

hemagglutinin

Answer 6

allows fusion to host cell membrane

Question 7

neuraminidase

Answer 7

allows virus to uncoat

Question 8

what does influenza cause?

Answer 8

necrosis of resp epithelium
little local inflam response
major systemic sympyoms

Question 9

primary and secondary reaction of influenza

Answer 9

primary- viral pneumonia: edema, necrosis of ciliated epithelium, lymphocytic infiltrates in submucosa
secondary- bacterial pneumonia: pathology of accute suppurative inflamation (s. aureus)

Question 10

influenza is spread via

Answer 10

droplets/aerosols

Question 11

how could you potentially prevent influenza from infecting?

Answer 11

blockade or disruption of receptors on cilia of resp cells

Question 12

what do the lungs look like in influenza pneumonia?

Answer 12

fluffy interstial infiltrates

Question 13

cytopathic

Answer 13

damage to host cell during infection

Question 14

measles

Answer 14

RNA virus

one strain without antigenic variation

Question 15

hemaggltinin of measles binds to

Answer 15

many types of cells by CD46, a complement regulatory protein

Question 16

what increases severity of disease?

Answer 16

suppression of cell-mediated immunity

rash requires cell mediated response though

Question 17

pneumonia

Answer 17

peribronchiolar and interstitial lymphocytic and mononuclear infiltrate

• lymphoid hyperplasia
• multinucleate syncytia cells in lung
• lymph nodes

Question 18

Warthin-Finkeldey

Answer 18

multinucleate syncytial cells in lungs

Question 19

what is on tongue in measles

Answer 19

koplik spots

Question 20

CMV

Answer 20

DNA herpes virus

opportunistic disease

Question 21

cells involved in CMV

Answer 21

epithelial cells

endothelial cells

Question 22

organs involved in CMV

Answer 22

lungs
liver
kidney
GI tract
CNS including retina

Question 23

where are inclusion bodies?

Answer 23

intranuclear

Question 24

how do you figure out if its a latent infection or the disease

Answer 24

measurement of viral load

Question 25

what do the CMV inclusion bodies look like

Answer 25

owl eyes in columnar epithelial cells

little surrounding inflammation of necrosis

Question 26

CMV can also lead to

Answer 26

retinitis in immunosuppressed patients