ID Toxicities Flashcards
Vancomycin
- Red Skin Rash (flushing, puritis, rash on face, neck, chest, upper extremities)
- Nephrotoxicity
- Ototoxicity
- thrombophlebitis
- interstitial nephritis
Metronidazole
- Metallic taste
- Stomatitis
- Peripheral neuropathy, seizures, encephalopathy
- Carcinogenic
- Teratogenic
Aminoglycosides
- Ototoxicity (irreversible)
- Nephrotoxicity (reversible)
Carbapenems
- GI
- Seizures, confusion, dizziness, hallucinations
Piperacillin, Nafcillin, Ticarcillin, Aqueous Sodium PCN G
Sodium overload (Tic worst) and Fluid Retention
- avoid in CHF and renal dysfxn pts
Linezolid
- Tongue discoloration
- Thrush
- Thrombocytopenia and anemia
- Peripheral and Optic Neuropathy
Polymyxins
- Nephrotoxicity
- Neurotoxicity (face and peripheral paralysis)
Macrolides
- Ototoxicity
- QTc Prolongation
- Thrombophlebitis and inf. site irritation (IV E and A)
- Erythromycin only: GI cramping (Ketal formation)
Cephalosporins
- Leukopenia, neutropenia or thrombocytopenia (>2week Tx)
- Biliary Sludging (Ceftriaxone)
- Pseudomembranous colitis
- Precipitation of Ceftriaxone w/ IV Calcium products
- Nonconvulsive status epilepticus (cefepime, ceftazidime, cefiderocol)
Tetracyclines
- chelate with metal ions = brown/grey teeth & dec bone growth
- N/V/D (tigecycline worst)
- Photosensitivity
- esophageal irritation
Synercid
- Venous Irritation
- Myalgias, arthralgias
Clindamycin
- Pseudomembranous colitis –> C. Diff
Daptomycin
- Myopathy and CPK elevation
- Acute Eosinophilic pneumonia
Nafcillin
- Interstitial Nephritis (fever, pyuria, eosinophiluira, abrupt inc in SCr)
- phlebitis
Cefamandole, Cefotetan, Cefmetazole, Cefoperazone, and Moxalactam
5-NMTT Side Chaine
- Hypoprothrombinemia (dec Vit. K -> inc risk of bleeding)
- Disulfiram rxn (EtOH intolerance)
PCNs
Neurologic (seizures, confusion, irritability, etc) in pts with renal dysfxn (Naf,Pip not affected)
- Leukopenia, neutropenia or thrombocytopenia
- Sodium overload and fluid retention (Tic,Pip)
- HypoKalemia (tic only)
Tela, Dalba, Oritavancin
- Red Man Syndrome
- TERATOGENIC
- Tela only: Nephrotoxicity, QTc prolongation, taste disturbance
Fluoroquinolones
- Hallucinations, delirium, seizures
- Periph neuropathy (BBW)
- damage to growing cartilage (AVOID in pregnancy)
- tendonitis
- QTc prolongation
Sulfonamides
- Crystalluria
- Rash
- Kernicterus in newborn
- Renal insufficiency
- HyperKalemia
- Photosensitivity
- Leukopenia
- Thrombocytopenia