ID Toxicities Flashcards
1
Q
Vancomycin
A
- Red Skin Rash
- Nephrotoxicity
- Ototoxicity
2
Q
Linezolid
A
- Tongue discoloration
- Thrush
- Thrombocytopenia
- Neuropathy
- Myelosuppression
3
Q
Aminoglycosides
A
- Ototoxicity (irreversible)
- Nephrotoxicity (reversible)
- Respiratory paralysis
4
Q
Macrolides
A
- Stevens-Johnson
- Long term use: cholestatic hepatitis (Jaundice)
- Epidermal necrolysis
- Erythromycin only: GI cramping (Ketal formation)
- pyloric stenosis in kids
SLEEP
5
Q
Clindamycin
A
- Pseudomembranous colitis –> C. Diff
- contact dermatitis (topical use)
6
Q
Tetracycline
A
- 4-epiHTC from dehyrdation = liver toxicity and Fanconi-like Syndrome
- ALL Tetracyclines: chelate with metal ions = brown/grey teeth
7
Q
Minocycline
A
- Vestibular toxicities (Vertigo, ataxia, nausea)
8
Q
Tigecycline
A
- Hepatoxicity (rare)
- pancreatitis
- anaphylactoid rxns
9
Q
Sarecycline
A
FETAL HARM
10
Q
Omadacycline
A
TERATOGENIC
11
Q
Chloramphenicol
A
- Aplastic Anemia (most serious)
- Bone Marrow suppression
- Childhood leukemia
12
Q
Quinolones
A
- Hallucinations, delirium, seizures
- Periph neuropathy
- damage to growing cartilage
- tendonitis
- Gatiflox: hyper/hypo BG
