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DRUGS > ID Toxicities > Flashcards

ID Toxicities Flashcards

1
Q

Vancomycin

A
  • Red Skin Rash (flushing, puritis, rash on face, neck, chest, upper extremities)
  • Nephrotoxicity
  • Ototoxicity
  • thrombophlebitis
  • interstitial nephritis
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2
Q

Metronidazole

A
  • Metallic taste
  • Stomatitis
  • Peripheral neuropathy, seizures, encephalopathy
  • Carcinogenic
  • Teratogenic
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3
Q

Aminoglycosides

A
  • Ototoxicity (irreversible)
  • Nephrotoxicity (reversible)
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4
Q

Carbapenems

A
  • GI
  • Seizures, confusion, dizziness, hallucinations
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5
Q

Piperacillin, Nafcillin, Ticarcillin, Aqueous Sodium PCN G

A

Sodium overload (Tic worst) and Fluid Retention
- avoid in CHF and renal dysfxn pts

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6
Q

Linezolid

A
  • Tongue discoloration
  • Thrush
  • Thrombocytopenia and anemia
  • Peripheral and Optic Neuropathy
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7
Q

Polymyxins

A
  • Nephrotoxicity
  • Neurotoxicity (face and peripheral paralysis)
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8
Q

Macrolides

A
  • Ototoxicity
  • QTc Prolongation
  • Thrombophlebitis and inf. site irritation (IV E and A)
  • Erythromycin only: GI cramping (Ketal formation)
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9
Q

Cephalosporins

A
  • Leukopenia, neutropenia or thrombocytopenia (>2week Tx)
  • Biliary Sludging (Ceftriaxone)
  • Pseudomembranous colitis
  • Precipitation of Ceftriaxone w/ IV Calcium products
  • Nonconvulsive status epilepticus (cefepime, ceftazidime, cefiderocol)
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10
Q

Tetracyclines

A
  • chelate with metal ions = brown/grey teeth & dec bone growth
  • N/V/D (tigecycline worst)
  • Photosensitivity
  • esophageal irritation
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11
Q

Synercid

A
  • Venous Irritation
  • Myalgias, arthralgias
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12
Q

Clindamycin

A
  • Pseudomembranous colitis –> C. Diff
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13
Q

Daptomycin

A
  • Myopathy and CPK elevation
  • Acute Eosinophilic pneumonia
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14
Q

Nafcillin

A
  • Interstitial Nephritis (fever, pyuria, eosinophiluira, abrupt inc in SCr)
  • phlebitis
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15
Q

Cefamandole, Cefotetan, Cefmetazole, Cefoperazone, and Moxalactam

A

5-NMTT Side Chaine
- Hypoprothrombinemia (dec Vit. K -> inc risk of bleeding)
- Disulfiram rxn (EtOH intolerance)

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16
Q

PCNs

A

Neurologic (seizures, confusion, irritability, etc) in pts with renal dysfxn (Naf,Pip not affected)
- Leukopenia, neutropenia or thrombocytopenia
- Sodium overload and fluid retention (Tic,Pip)
- HypoKalemia (tic only)

17
Q

Tela, Dalba, Oritavancin

A
  • Red Man Syndrome
  • TERATOGENIC
  • Tela only: Nephrotoxicity, QTc prolongation, taste disturbance
18
Q

Fluoroquinolones

A
  • Hallucinations, delirium, seizures
  • Periph neuropathy (BBW)
  • damage to growing cartilage (AVOID in pregnancy)
  • tendonitis
  • QTc prolongation
19
Q

Sulfonamides

A
  • Crystalluria
  • Rash
  • Kernicterus in newborn
  • Renal insufficiency
  • HyperKalemia
  • Photosensitivity
  • Leukopenia
  • Thrombocytopenia

DRUGS (35 decks)

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