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Cancer Drugs Classes/Targets Flashcards

1
Q

Osimertinib

A
  • Kinase-i
  • EGFR-i (inhibits T790M mutation)
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2
Q

BlinatumUmab

A
  • Bispecific antibody (T cell Engager) (BiTE)
  • binds CD3 to CD19
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3
Q

Tucatinib

A
  • Kinase-i
  • HER2-i &TKI
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4
Q

M Phase

A

Microtubule-i

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5
Q

Alectinib

A
  • Kinase-i
  • EML4-ALK-i
  • genetic testing for mutation
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6
Q

Cyclophosphamide

A
  • Alkylator
  • Prodrug –> phosphoramide mustard (PM)
  • Add Mesna to decrease acrolein (byproduct)
  • D-L: Hemorrhagic cystitis
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7
Q

Midostaurin

A
  • Kinase-i
  • FLT3-i (broad)
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8
Q

Methotrexate

A
  • Antifolate
  • DHFR-i (inhibits TMP synthesis)
  • RM: inc. DHFR and dec. polyglutamation
  • Rescue: Leucovorin (rescues toxic effects)
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9
Q

Bortezomib

A
  • Proteasome-i
  • SE: neuropathy
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10
Q

Abiraterone

A
  • Endocrine
    -17alpha-hydrolase and C17,20 lyase-i
  • SE: inc. cholesterol
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11
Q

6-Mercaptopurine (6-MP)

A
  • Antimetabolite
  • Purine analog (inhibits purine synthesis)
  • RM: loss of HGPRT (activating enzyme)
  • inactivated by TPMT
  • DrugI: Allopurinol
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12
Q

Fulvestrant

A
  • Endocrine
  • SERD (selective estrogen receptor down-modulator)
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13
Q

Leuprolide

A
  • Endocrine
  • GnRH Analog
  • SE: gynecomastia, sex dysfxn
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14
Q

PembroliZUmab

A
  • Antibody
  • targets PD-1 (blocks interaction with PD-L1)
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15
Q

Cytarabine (Ara-C)

A
  • Antimetabolite
  • Cytosine Analog (inhibits DNA polymerase)
  • Prodrug –> Ara-CTP
  • RM: inc. cytidine deaminase (CDA)
  • Synergy: Tethrahydrouridine (CDA-i)
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16
Q

Gefitinib

A
  • Kinase-i
  • EGFR-i (Exon 19 or 21) (L858R)
  • RM: T790M mutation
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17
Q

G2 Phase

A
  • Top2-i (Etoposide and Bleomycin)
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18
Q

CAR-T

A
  • Cell-based Tx
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19
Q

Venetoclax

A
  • Anti-Apoptotic protein-i
  • BCL-2-i
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20
Q

RituXImab

A
  • Antibody
  • targets CD20 (B cell/ Non-Hodgkin’s)
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21
Q

CetuXImab

A
  • Antibody
  • EGF-i
  • SEVERE infusion rxn
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22
Q

Imatinib

A
  • Kinase-i
  • Bcr-Abl-i
  • RM: T3151 mutation
  • Tox: fluid retention and edema
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23
Q

Sipulcel-T (Provenge)

A
  • Cell-Based Tx
  • PAP-GM-CSF
  • “Therapeutic Vaccine”
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24
Q

G1 Phase

A
  • CDK4/6-i
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25
TrastuZUmab
- Antibody - targets HER2 - combo with Pertu and Docetaxel
26
TrastuZUmab Emtansine
- Antibody-drug conjugate - HER2 antibody - microtubule destabilizer
27
Letrozole
- Endocrine - Aromatase-i (non-steroidal)
28
Enzalutamide
- Endocrine - Androgen Receptor Antagonist
29
Erubulin
- Microtubule-i - microtubule polymerization-i (destabilizer) - Lower rate of neurotoxicity than Vinca Alkaloids)
30
PertuZUmab
- Antibody - targerts HER2 (prevents dimerization) - combo with Trastu and Docetaxel
31
Taquetamab
- Bispecific antibody (T cell Engager) (BiTE) - binds CD3 with GPRC5D
32
Ponatinib
- Kinase-i - Bcr-Abl-i (inhibits T3151 mutation)
33
Cisplatin
- Platinum Compound - Prodrug --> Aquo form - D-L: Nephrotoxicity (proximal tubule)
34
Teclistamab
- Bispecific antibody (T cell Engager) (BiTE) - binds CD3 with BCMA (B cell maturation antigen)
35
Lapatinib
- Kinase-i - EGFR-i & HER2-i - SE: reversible dec. in cardiac function
36
Doxorubicin
- Top2-1 - intercalates (free radicals) - SE: cardiotoxicity (iron-catalyzed free radical formation), extravasation - add Dexrazoxane to dec. cardiotoxicity
37
S phase
- Anti-Metabolites - Anti-Folates - Top1-i
38
Non-Cell Cycle Specific
- Alkylators - Platinum Compounds - Top2-i (Doxorubicin)
39
5-Azacytosine
- DNA Methylation-i - DNMT-i (reactivation of tumor suppressor genes)
40
Olaparib
- Kinase-1 - PARP-i (traps PARP to DNA) - need BRCA mutation for PARP-i to work (BRCA is a tumor suppressor) - "synthetic lethality"
41
Afatinib
- Kinase-i - Covalent EGFR-i (Exon 19 or 21) - RM: T790M mutation - genetic test for mutation
42
Paclitaxel
- Microtubule-i (taxane) - Microtubule stabilizer - D-L: myelosuppresion - Linked to albumin
43
Exemestane
- Endocrine - Aromatase-i (steroidal)
44
Vincristine
- Microtubule-i (Vinca Alkaloid) - Microtubule Destabilizers - D-L: neurotoxicity - SE: extravasation - Rm: pGP
45
Quizartinib
- Kinase-i - FLT3-i (ITD mutation)
46
DaratumUmab
- Antibody - targets CD 38 (plasma B cell)
47
Pomalidomide
- thalidomide analog - degrades IKZF TFs - Needs POMALYST and REMS
48
Etoposide
- Top2-i - doesn't intercalate (no free radicals)
49
Acalabrutinib
- Kinase-i - BTK-i
50
Dabrafenib
- Kinase-i - BRAF-V600-i - Combo with Trametinib (b/c Dabraf induces squamous cell carcinomas)
51
Sirolimus
- Kinase-i - Rapamycin Analog (mTOR-i) (blocks IL-2 signaling)
52
Irinotecan
- Top1-i - RM: pGP, MRP, GST
53
AtezoliZUmab
- Antibody - binds PD-L1 (blocks interaction with PD-1)
54
Bleomycin
- glycopeptide antibiotic (Top2-i) - free radicals cause DNA breaks - SE: Pulmonary toxicity and Rash (low levels of bleo aminohydrolase in skin and lungs) - RM: inc. bleo aminohydrolase
55
MosunetuZUmab
- Bispecific antibody (T cell Engager) (BiTE) - binds CD3 with CD20 - D-L: cytokine storm
56
Mitomycin C
- Alkylator - D-L: myelosuppression
57
RamucirUmab
- Antibody - VGEF-i (binds receptor)
58
Tamoxifen
- Endocrine - SERM (selective estrogen receptor modulator) - Prodrug (CYP2D6)
59
Palbociclib
- Kinase-i - CDK4/6-i (stops phosphorylation of Rb) - involved in cell-cycle control
60
TrastuZUmab Deruxtecan
- Antibody-drug conjugate - HER2 antibody - Top1-i
61
BevaciZUmab
- Antibody - VGEF-i (binds ligand)
62
5-FU
- Antimetabolite - Uridine Analog (inhibit thymidylate synthase) - Prodrug --> FdUMP - RM: dec. of enzyme that 5-FU-> FdUMP - Rescue: Thymidine - Synergy: Leucovorin - metabolized by DPD
63
IpilimUmab
- Antibody - targets CTLA-4 (Remove Emergency breaks) (reverses CTL inhibition) - SE: inflammatory response (may need high-dose corticosteroid)
64
Ixabepilone
- Microtubule-i (Epothilones) - Microtubule stabilizers
65
Chlorambucil
- Alkylator
66
Trametinib
- Kinase-i - MEK1 & MEK2-i - can't use if pt already received BRAF-i Tx
67
Crenolanib
- Kinase-i - FLT3-i (more specific)

DRUGS (37 decks)

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