ID: RNA Viruses Flashcards
If someone is deficient in the MAC attack complex - complement 5, 6, 7,8 - what are they susceptible to?
Neisseria infections
Why do RNA viruses have a high rate of mutations?
RNA polymerases dont proofread
What are the most common viruses that cause the common cold?
rhinovirus - a picornavirus
coronavirus
Besides the common cold, what else can the coronavirus cause?
SARS
What specifically causes cold like symptoms?
bradykinin release
What type of influenza is most common and most severe?
type A
What mediates fusion of the influenza virus?
hemagluttinin
If someone has an infection with the flu what are they susceptible to and why?
destruction of the ciliated epithelium –> bacterial infection
examples: S pneumonia, S aureus
What illness does RSV cause?
bronchiolitis and pneumonia in kids <1
What cells are pathologically present in a measles infection?
warthin finkeldey giant cells
What infection “Four Ds and Four Cs” - 4 day fever, cough, coryza (head cold), conjunctivitis
Measles
Describe the rash that is pathognomonic for Measles
KOPLIK spots:
- grey spots on red base
- T cell mediated vasculitis
- begins on face and spreads to trunk
What is an unfortunate complication of Measles?
Subacute sclerosing panencephalitis - slow neurodegen. disorder years after infection
What comprises TORCH
T toxoplasmos O other - coxsackie, syphilis, varicella, chlamydia, HIV R rubella C CMV H HSV2
all are vertically transmitted diseases
What infection “fever, painful swelling of the parotid gland with possible testicular swelling”
Mumps
