ID: DNA Viruses Flashcards
What is the pathognomonic feature of Herpes viruses on microscopy?
intranuclear inclusion bodies
Name the latency:
- VZV
- HSV1
- HSV2
- EBV
- CMV
- DRG
- Trigem
- Sacral ganglia
- B cells
- Mononuclear cells
Describe the rash in chickenpox
asynchronous rash - crops of vesicles
Describe the rash in shingles
vesicles on one dermatome
Describe the rash in HSV1
dew drops on a rose
What is the number one cause of meningoencephalitis in the US?
HSV1 infection
If a mom is pregnant and has HSV2 infection, what does she put her baby at risk for?
disseminated HSV2 infection in the newborn with liver involvement and can cause meningoencephalitis
Where are the lesions located in meningoencephalitis infection with HSV1?
temporal lobe
KNOWW DISS
What cells does EBV infect?
nasopharyngeal and B cells - both have CD21
What cells are pathognomonic for EBV infection?
atypical lymphocytes - have vacuolated cytoplasm
-T cells are activated to kill the mitogenic infected B cells
Name five diseases EBV can cause besides mono and where/in who do they occur
- lymphoproliferative disorders - IC
- hairy oral leukoplakia - IC
- Burkitts lymphoma - Africa
- Hodkins lymphoma
- Nasopharyngeal - Asia
How do you diagnose EBV infection
heterophile + antibody test
What is pathognomonic for CMV infection?
owls eye inclusion
What is the classic infection that CMV causes in a neonate?
“blueberry muffin baby” - TTP and widespread necrosis
What do you worry about with CMV + transplants?
reactivation and interstitial pneumonitis in transplant patients
