ID drugs Flashcards
aminoglycosides MOA
bind to ribosome (interfere with protein synthesis)
aminoglycosides coverage
gram negative, pseudomonas
aminoglycosides boxed warnings
nephrotoxicity, ototoxicity, neuromuscular blockade, respiratory paralysis
aminoglycoside dosing is based on
weight
aminoglycoside dose opitmization is dependent on
concentration (less frequency but higher dosing to achieve higher peaks)
quinolones MOA
inhibit topo IV and DNA gyrase
quinolones coverage
gram negative and positive, atypicals
respiratory quinolones
levofloxacin, moxifloxacin (enhanced coverage of S. pneumoniae and atypicals
quinolones that cover pseudomonas
ciprofloxacin, levofloxacin
which quinolone should not be used in UTI
moxifoxacin bc it does not concentrate in the urine
which quinolone is not use in CAP
ciprofloxacin bc no strep pneumoniae coverage
preferred quinolone for MRSA skin infection
delafloxacin
quinolone boxed warnings
tendon rupture, peripheral neuropathy, CNS effects (seizure)
quinolones can inc effect of
warfarin, sulfonylureas, insulin
major warnings for quinolones
QT prolongation, hypo/hyperglycemia
quinolone with no renal adjustments
moxifloxacin
macrolide MOA
bind 50S ribosomal subunit
macrolide coverage
atypicals, haemophilus influenzae
macrolide contraindication
cholestatic jaundice/hepatic dysfunction with prior use; clarithro/erythro-mycin with lovastatin or simvastatin
macrolide major warnings
QT prolongation, hepatotoxicity
macrolide SE
GI, ototoxicity, skin rxns
tetracycline MOA
bind 30S ribosomal subunit
tetracycline coverage
gram positive and negative, atypicals
vibramycin
doxycycline
