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NAPLEX > ID drugs > Flashcards

ID drugs Flashcards

1
Q

aminoglycosides MOA

A

bind to ribosome (interfere with protein synthesis)

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2
Q

aminoglycosides coverage

A

gram negative, pseudomonas

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3
Q

aminoglycosides boxed warnings

A

nephrotoxicity, ototoxicity, neuromuscular blockade, respiratory paralysis

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4
Q

aminoglycoside dosing is based on

A

weight

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5
Q

aminoglycoside dose opitmization is dependent on

A

concentration (less frequency but higher dosing to achieve higher peaks)

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6
Q

quinolones MOA

A

inhibit topo IV and DNA gyrase

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7
Q

quinolones coverage

A

gram negative and positive, atypicals

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8
Q

respiratory quinolones

A

levofloxacin, moxifloxacin (enhanced coverage of S. pneumoniae and atypicals

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9
Q

quinolones that cover pseudomonas

A

ciprofloxacin, levofloxacin

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10
Q

which quinolone should not be used in UTI

A

moxifoxacin bc it does not concentrate in the urine

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11
Q

which quinolone is not use in CAP

A

ciprofloxacin bc no strep pneumoniae coverage

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12
Q

preferred quinolone for MRSA skin infection

A

delafloxacin

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13
Q

quinolone boxed warnings

A

tendon rupture, peripheral neuropathy, CNS effects (seizure)

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14
Q

quinolones can inc effect of

A

warfarin, sulfonylureas, insulin

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15
Q

major warnings for quinolones

A

QT prolongation, hypo/hyperglycemia

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16
Q

quinolone with no renal adjustments

A

moxifloxacin

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17
Q

macrolide MOA

A

bind 50S ribosomal subunit

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18
Q

macrolide coverage

A

atypicals, haemophilus influenzae

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19
Q

macrolide contraindication

A

cholestatic jaundice/hepatic dysfunction with prior use; clarithro/erythro-mycin with lovastatin or simvastatin

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20
Q

macrolide major warnings

A

QT prolongation, hepatotoxicity

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21
Q

macrolide SE

A

GI, ototoxicity, skin rxns

22
Q

tetracycline MOA

A

bind 30S ribosomal subunit

23
Q

tetracycline coverage

A

gram positive and negative, atypicals

24
Q

vibramycin

A

doxycycline

25
Q

doxycycline clincial pearl

A

no renal adjustments

26
Q

Tetracycline warnings

A

bone deformation/teeth discoloration for <8y, photosensitivity

27
Q

sulfamethoxazole/trimethoprim inhibits

A

folic acid pathway

28
Q

bactrim coverage

A

broad gram negative, opportunistic

29
Q

bactrim single strength

A

400/80

30
Q

bactrim double strength

A

800/160

31
Q

bactrim major side effects

A

photosensitivity, hyperkalemia, crystalluria

32
Q

cdiff treatment

A

vancomycin 125 mg PO X10 days

33
Q

major side effects of vancomycin

A

ototoxicity, nephrotoxicity

34
Q

vancomycin goal trough

A

10-15; 15-20 if serious infection

35
Q

vancomycin goal AUC:MIC

A

400-600

36
Q

vancomycin is weight based. which weight is used?

A

total body weight

37
Q

daptomycin odsing is dependent on

A

concentration (Cmax:MIC)

38
Q

daptomycin warnings

A

myopathy, rhabdomyolysis (inc CPK)

39
Q

why is daptomycin not used in pneumonia

A

inactivated by surfactants in lungs

40
Q

linezolid MOA

A

50S subunit

41
Q

linezolid major side effect

A

dec platelets

42
Q

tigecycline spectrum

A

gram positive, gram negative, anaerobes, atypicals; not the 3 Ps (pseudomonas, proteus, providencia)

43
Q

polymixins major side effect

A

nephrotoxicity, neurotoxicity

44
Q

chloramphenicol warning

A

gray syndrome

45
Q

clindamycin boxed warning

A

c diff

46
Q

metronidazole coverage

A

anaerobes, protozoal

47
Q

metronidazole side effect

A

metallic taste

48
Q

metronidazole interaction

A

alcohol (disulfiram like rxn)

49
Q

fidaxomicin indication

A

c diff

50
Q

rifaximin indication

A

traveler’s diarrhea, IBS with diarrhea, dec hepatic encephalopathy

51
Q

macrobid dosing

A

100 mg bid X5 days

NAPLEX (10 decks)

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