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NAPLEX > Constipation/Diarrhea > Flashcards

Constipation/Diarrhea Flashcards

1
Q

medical conditions that cause constipation

A

IBS, anal disorders, MS, CV events, PD, spinal cord tumors, diabetes, hypOthyroidism

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2
Q

nondrug tx for constipation

A

inc fluids, limit caffiene and alcohol, inc physical activity, inc fiber

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3
Q

what drugs cause constipation

A

antacids, antidiarrheals, clonidine, colesevelam, anticholinergics, iron, non dhp CCBs, opioids, sucralfate

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4
Q

pts should be refered to physician if constipation persists after how many days of OTC tx

A

7 days

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5
Q

bulk forming drugs

A

psyllium (fiber)

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6
Q

drug of choice for constipation in pregnancy

A

psyllium (fiber)

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7
Q

osmotics

A

PEG, magnesium hydroxide, glycerin, lactulose

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8
Q

stimulants

A

senna, bisocodyl

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9
Q

drug of choice for opioid induced constipation

A

stimulants (senna, bisocodyl) or osmotic

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10
Q

stool softener

A

docusate

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11
Q

lubricants

A

mineral oil

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12
Q

metamucil

A

psyllium

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13
Q

dulcolax

A

bisacodyl

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14
Q

colace

A

docusate

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15
Q

drug of choice for constipation with straining

A

stool softeners (docusate, senna)

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16
Q

mineral oil contraindications

A

<6y, pregnant, bedridden, elderly, difficulty swallowing

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17
Q

lubiprostone moa

A

chloride channel activator

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18
Q

lubiprostone contraindication

A

mechanical bowel obstruction

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19
Q

linaclotide (linzess) contraindications

A

<6y, mechanical GI obstruction

20
Q

drug indicated for hospitalized surgery patients to decrease risk of post op ileus

A

alvimopan

21
Q

laxatives for wbi should be used with caution in which patients

A

CVD, reanl insufficiency, taking loops or NSAIDs

22
Q

alvimopan (entereg) contraindication and max doses

A

opioid use > 7 consecutive days; 15 doses

23
Q

constipation drugs only used for OIC

A

methylnaltrexone, naloxegol, naldemedine

24
Q

drugs that cause diarrhea

A

AChE Inhibitors, Mg, antibiotics, antidiabetics, antineoplastics, colchicine, laxatives, misoprostol, mycophenolate, metoclopramide, protease inhibitors, quinidine, roflumilast

25
Q

most common bacterial cause for diarrhea

A

e coli

26
Q

non-drug diarrhea treatment

A

fluid and electrolyte replacement

27
Q

antidiarrheal agents

A

bismuth subsalicylate, loperamide, lomotil

28
Q

loperamide boxed warning

A

torsades, cardiac arrest, do not exceed recommended dose

29
Q

major pepto bismol side effects

A

black tongue/stool, nausea, bleeding/bruising

30
Q

lomotil cds class

A

C-V

31
Q

dicyclomine warnings

A

anticholinergic, mild-mod UC

32
Q

eluxadoline (vibrezi) contraindication

A

patients without a gallbladder

33
Q

do not take loperamide for longer than

A

2 days

34
Q

Eluxadoline (Vibrezi) MOA

A

peripherally acting mixed Mu opioid agonist

35
Q

Methylnaltrexone

A

Relistor

36
Q

Naloxegol

A

Movantik

37
Q

Prucalopride MOA and warning

A

5HT4 agonist; suicidal ideation

38
Q

Imodium bbw and CI

A

Bbw: cardiac arrest with higher doses
CI: c diff, dysentery, enterocolitis

39
Q

Lomotil (diphenoxylate/atropine) CI, side effects and max dose

A

CI: <2y, <6y if tablets
SE: mild euphoria
Max 20 mg/day

40
Q

drug used to treat constipation that is only available Rx

A

lactulose

41
Q

osmoprep boxed warning

A

nephropathy

42
Q

first line OIC tx

A

stimulant laxative

43
Q

PAMORAs

A

alvimopan, mathylnaltrexone, naloxegol, naldemedine

44
Q

amitiza common se

A

nausea

45
Q

linaclotide (linzess) MOA

A

guanylate cyclase C agonist

NAPLEX (10 decks)

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