ID and Abx

Question 1

Cardiovascular side effect of fluoroquinolones and macrolides

Answer 1

QT prolongation

Question 2

What Abx generally work for Vibrio infections?

Answer 2

doxycycline (+/- cephalosporins) or a fluoroquinolone

Question 3

Is Abx therapy always necessary in Vibrio gastroenteritis?

Answer 3

No (may even prolong illness), but should be given if high fever or bacteremia.

Question 4

Serum levels of _______ are elevated (usu. >220 IU/L) in HIV pts w/PCP.

Answer 4

LDH

Question 5

What is the backbone of any HAART regimen?

Answer 5

2 NRTIs + 1 PI or NNRTI

Question 6

What old protease inhibitor is now used only as a booster for HAART b/c it limits hepatic metabolism of ARVs and allows smaller doses to be used?

Answer 6

Norvir (ritonavir)

Question 7

Name the 2 most important lab tests when a pt. is first Dxed w/ HIV.

Answer 7

CD4+ ct. and viral load

Question 8

What infections would you test for in your initial HIV workup?

Answer 8

HBV, HCV, CMV, TB, Toxoplasma serology

Question 9

What other lab test will help determine drug regimen in initial HIV workup?

Answer 9

resistance profile

Question 10

Treatment for disseminated cryptococcal infection

Answer 10

Conventional amphotericin B and flucytosine